Objective: The primary objective of this systematic review is to present current knowledge about the oncobiome of gynecological cancers.Methods: Our systematic review contains data about the oncobiome of uterine corpus cancer, ovarian cancer and cervical cancer. Articles about other gynecological cancers were excluded.Results: A total of 72 articles were included in our systematic review. In uterine corpus cancer, cervical cancer and ovarian cancer, representatives of bacteria, fungi, viruses and parasites can be found. The oncobiome of ovarian cancer is connected with the oncobiome of head and neck cancers. Our systematic review proved that the human papilloma virus is connected with ovarian and cervical cancer. Gut dysbiosis can be used as a marker of ovarian cancer. In cervical cancer, we found the difference between the microbiota of healthy patients and patients with cervical cancer.Methylobacter,Robignitomaculum,Klebsiella,MicromonosporaandMicrobisporahave an impact on overall survival. The microbiome of uterine corpus cancer is more differentiated than in cancer-free samples. Chronic endometrial inflammation has an impact on endometrial microbiome.Discussion: Treatment of gynecological cancers is changing permanently. Chemotherapy, as a systematic treatment, is being left in the past. Modern methods of therapy are addressed to specific genes. In the past, researchers claimed that tumors are sterile. However, the newest research indicates that malignancies were found to have genetic fragments of pathogens, which can be used as vectors for medications or as markers for the detection of a specific malignancy. Three most common gynecological cancers are as follows: endometrial cancer, ovarian cancer and cervical cancer. Each of these has their specific microbiome, which can be used for oncological treatment. These discoveries create possibilities for new, efficient methods of treatment. This systematic review analyzes publications about the composition of the gynecological tumor microenvironment, correlation between microbiomes of different organs, the female reproductive tract and the microbiome of the female reproductive tract during malignancy. Moreover, we provide information on the influence of some pathogens on the treatment.
目的：本系统综述的主要目的是呈现当前关于妇科癌症肿瘤微生物组的知识现状。 方法：本系统综述包含了关于子宫体癌、卵巢癌和宫颈癌肿瘤微生物组的数据。其他妇科癌症的相关文章被排除在外。 结果：本系统综述共纳入72篇文章。在子宫体癌、宫颈癌和卵巢癌中，均发现了细菌、真菌、病毒和寄生虫的代表性存在。卵巢癌的肿瘤微生物组与头颈部癌症的肿瘤微生物组存在关联。本系统综述证实了人乳头瘤病毒与卵巢癌和宫颈癌相关。肠道菌群失调可作为卵巢癌的标志物。在宫颈癌中，我们发现了健康患者与宫颈癌患者之间微生物群的差异。甲基杆菌属、罗比尼氏菌属、克雷伯菌属、小单孢菌属和小双孢菌属对总生存期有影响。子宫体癌的微生物组比无癌样本更具差异性。慢性子宫内膜炎症对子宫内膜微生物组有影响。 讨论：妇科癌症的治疗正在不断变化。化疗作为一种系统性治疗正逐渐成为过去。现代治疗方法针对特定基因。过去，研究人员认为肿瘤是无菌的。然而，最新研究表明，恶性肿瘤中存在病原体的基因片段，这些片段可用作药物载体或作为检测特定恶性肿瘤的标志物。三种最常见的妇科癌症分别是子宫内膜癌、卵巢癌和宫颈癌。每种癌症都有其特定的微生物组，可用于肿瘤治疗。这些发现为开发新的高效治疗方法创造了可能性。本系统综述分析了关于妇科肿瘤微环境组成、不同器官微生物群之间的相关性、女性生殖道微生物群以及恶性肿瘤期间女性生殖道微生物群的文献。此外，我们还提供了一些病原体对治疗影响的信息。
肿瘤(癌症)患者之家