Background/Objectives: Patients with pancreatic neuroendocrine tumors (PanNETs) often have a good prognosis with long overall survival. We evaluated quality of life (QoL) after surgery for PanNETs, using the new EORTC-specific questionnaires.Methods: PanNET patients operated on in our unit (1990–2023) received three EORTC questionnaires (QLQ-C30 and the new P.NET15 and P.NET19). We evaluated the following: (1) QLQ-C30 outcomes; (2) mixed domains from QLQ-C30, P.NET15, and P.NET19; and (3) domains from P.NET19 and P.NET15 only. Functional and symptom scales were investigated in relationship with clinical variables. Gamma regression and multivariable analyses were performed with R software.Results: The 100 patients enrolled (median time 133 months after surgery) showed a good QoL (median 83.3/100). Old age was related to worse QoL and physical functioning (p= 0.007 andp< 0.001, respectively). Diabetes negatively influenced QoL (p< 0.001), physical functioning (p= 0.005), and fatigue (p= 0.03). Patients undergoing parenchyma-sparing surgery showed less fatigue (p= 0.046), while non-insulinoma PanNET diagnosis was related to worse QoL (p= 0.039). Multiple comorbidities were negatively associated with physical functioning (p= 0.010), fatigue (p= 0.001), and pain (p= 0.021). According to the new questionnaires, the most affected outcome was muscle energy, depending on age (p= 0.042), diabetes (p= 0.014), type of surgery (p= 0.018), and non-insulinoma diagnosis (p= 0.007).Conclusions: A good QoL evaluated with EORTC questionnaires is reported in PanNET patients after surgery. Elderly and diabetic patients who underwent standard resection for gastrinoma/non-functioning PanNETs showed worse QoL outcomes.
背景/目的：胰腺神经内分泌肿瘤（PanNETs）患者通常预后良好，总体生存期较长。本研究采用欧洲癌症研究与治疗组织（EORTC）新开发的专用问卷，评估了PanNET患者术后的生活质量（QoL）。 方法：对1990年至2023年间在本中心接受手术的PanNET患者发放三份EORTC问卷（QLQ-C30及新开发的P.NET15与P.NET19）。评估内容包括：（1）QLQ-C30结果；（2）QLQ-C30、P.NET15和P.NET19的混合维度；（3）仅P.NET19和P.NET15的维度。通过R软件进行伽马回归与多变量分析，探讨功能量表及症状量表与临床变量的关联性。 结果：纳入的100例患者（术后中位时间133个月）显示良好的生活质量（中位得分83.3/100）。高龄与较差的生活质量及躯体功能相关（p值分别为0.007和<0.001）。糖尿病对生活质量（p<0.001）、躯体功能（p=0.005）和疲劳症状（p=0.03）产生负面影响。接受保留实质手术的患者疲劳程度较低（p=0.046），而非胰岛素瘤型PanNET诊断与较差的生活质量相关（p=0.039）。多种合并症与躯体功能（p=0.010）、疲劳（p=0.001）和疼痛（p=0.021）呈负相关。根据新问卷评估，受影响最显著的指标是肌肉能量，其与年龄（p=0.042）、糖尿病（p=0.014）、手术类型（p=0.018）及非胰岛素瘤诊断（p=0.007）相关。 结论：通过EORTC问卷评估显示，PanNET患者术后生活质量总体良好。接受标准切除术的老年糖尿病患者及胃泌素瘤/无功能PanNET患者的生活质量结局较差。
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