Cutaneous metastases (CMs) represent an uncommon but clinically significant manifestation of advanced malignancies, originating from both solid and non-solid cancers. This review explores the clinical characteristics and prognostic implications of CMs. For solid cancers, CMs are most frequently associated with primary malignancies of the breast, lung, and gastrointestinal tract, presenting as nodules, plaques, or ulcerative lesions. In contrast, CMs from non-solid cancers, such as hematologic malignancies, often exhibit distinct patterns, including diffuse infiltrates or erythematous plaques, mimicking inflammatory dermatoses. Clinical features, as well as dermoscopy, may help, but diagnostic confirmation relies on histopathological evaluation and immunohistochemical studies, which are essential for determining the primary source of the malignancy. Clinically, CMs often signify a poor prognosis, necessitating prompt recognition and tailored management to improve patient outcomes. This comprehensive review aims to enhance clinical understanding and awareness of CMs to facilitate early diagnosis and optimized treatment strategies.
皮肤转移瘤是晚期恶性肿瘤一种虽不常见但具有重要临床意义的表现形式，可源自实体瘤与非实体瘤。本文综述探讨皮肤转移瘤的临床特征及预后意义。在实体瘤中，皮肤转移最常见于乳腺、肺及胃肠道的原发性恶性肿瘤，常表现为结节、斑块或溃疡性病变。相比之下，源自非实体瘤（如血液系统恶性肿瘤）的皮肤转移则常呈现不同的模式，包括弥漫性浸润或红斑性斑块，其表现类似炎症性皮肤病。临床特征及皮肤镜检查可提供辅助诊断线索，但确诊仍需依靠组织病理学评估和免疫组化研究，这对确定恶性肿瘤的原发来源至关重要。临床上，皮肤转移通常提示预后不良，需要及时识别并采取个体化治疗以改善患者结局。本综述旨在提升临床对皮肤转移瘤的认识与理解，以促进早期诊断和优化治疗策略。
Clinical Aspects of Cutaneous Metastasis from Non-Cutaneous Primary Tumors
肿瘤(癌症)患者之家