Indocyanine green (ICG) is a fluorescent agent which is characterized by a wide range of applications in the proper visualization of the operating field, differentiation of vital structures, and localization of lesions to be excised. An investigation and overview of novel approaches of indocyanine green in modern gynecological oncology was conducted, including ovarian cancer surgery with its compartmental approach and compartmental surgery in endometrial cancer. Ureteral visualization and perfusion, lymphography, lymph node transfers, or the localization of anastomotic leakage in bowel surgery are examples of applications aimed at reducing the risk of surgical complications and improving the patients’ quality of life. The general use of indocyanine green in lymph node detection, subcategorized and analyzed, is constantly improved and reviewed. A therapeutic approach with macromolecules is being tested in preclinical models. Early results could suggest the future application of indocyanine green not only in broad-sense imaging but also as a cytotoxic agent conjugated with macromolecules. Further studies on the application of indocyanine green in laparoscopy, open surgery, and finally as a curative cytotoxic agent are needed.
吲哚菁绿是一种荧光显影剂，其特点在于能够广泛应用于手术视野的清晰显影、重要结构的鉴别以及待切除病灶的定位。本研究对吲哚菁绿在现代妇科肿瘤学中的创新应用进行了系统调查与综述，包括卵巢癌手术中的区域解剖入路及子宫内膜癌的区域性切除术。在输尿管显影与灌注评估、淋巴造影、淋巴结示踪以及肠道手术中吻合口漏定位等方面的应用，均旨在降低手术并发症风险并提升患者生活质量。吲哚菁绿在淋巴结检测中的总体应用经过细分归类与分析，正处于持续改进与评估阶段。基于大分子载体的治疗策略正在临床前模型中进行验证，初步研究结果提示吲哚菁绿未来不仅可广泛应用于影像学领域，还可作为与大分子结合的细胞毒性药物。未来需进一步开展吲哚菁绿在腹腔镜手术、开放手术中的应用研究，并最终探索其作为治疗性细胞毒性药物的潜力。
肿瘤(癌症)患者之家