Background:Hand tumors encompass a heterogeneous spectrum of benign, malignant, and tumor-like lesions with diverse clinical behavior. While international studies have reported epidemiological and clinicopathological features, large-scale data in Italian populations are scarce. This retrospective analysis represents one of the largest Italian surgical series of histologically confirmed hand tumors. The objective was to evaluate clinicopathological characteristics, anatomical distribution, and surgical outcomes of these lesions over a 5-year period.Methods:A total of 250 patients who underwent surgery for hand tumors at the Department of Plastic and Reconstructive Surgery, University Hospital “G. Martino,” Messina, Italy, from January 2020 to December 2024, were retrospectively reviewed. Data from clinical records, imaging, and histopathology were categorized as tumor-like lesions, benign neoplasms, or malignant tumors. Demographic and clinical variables were compared across diagnostic groups.Results:The cohort included 127 males and 123 females (mean age 49.3 ± 18.6 years). Lesions were most frequently located in the digits (62%), followed by palm (21%), dorsum (11%), and wrist (6%). Tumor-like lesions represented 37.6% of cases, predominantly mucous cysts and foreign body granulomas. Benign tumors accounted for 49.2%, with giant cell tumors of the tendon sheath as the most common (31.7%). Malignant tumors were rare (10.4%), mainly squamous cell carcinoma, basal cell carcinoma, and melanoma. Patients with malignant lesions were significantly older (67.4 years) compared with those with benign or tumor-like lesions (p< 0.01).Conclusions:Benign and tumor-like lesions predominate among hand tumors, whereas malignancies are infrequent but clinically important. Surgical excision remains the treatment of choice, guided by preoperative imaging and confirmed histopathologically. Expanding this cohort and integrating molecular diagnostics with patient-reported outcomes may enhance future management strategies.
背景：手部肿瘤涵盖一系列异质性的良性、恶性及瘤样病变，其临床行为表现多样。尽管国际研究已报道相关流行病学及临床病理特征，但意大利人群的大规模数据仍较为缺乏。本回顾性分析是意大利最大规模经组织学确诊的手部肿瘤外科病例系列之一，旨在评估这些病变在五年间的临床病理特征、解剖分布及手术结果。 方法：回顾性分析了2020年1月至2024年12月期间在意大利墨西拿大学医院“G. Martino”整形与重建外科接受手部肿瘤手术的250例患者。根据临床记录、影像学及组织病理学资料，将病变分为瘤样病变、良性肿瘤或恶性肿瘤。比较不同诊断组间的人口统计学及临床变量。 结果：队列包括127例男性和123例女性（平均年龄49.3±18.6岁）。病变最常见于指部（62%），其次为手掌（21%）、手背（11%）和腕部（6%）。瘤样病变占37.6%，主要为黏液囊肿和异物肉芽肿。良性肿瘤占49.2%，其中腱鞘巨细胞瘤最为常见（31.7%）。恶性肿瘤罕见（10.4%），主要为鳞状细胞癌、基底细胞癌和黑色素瘤。恶性病变患者平均年龄（67.4岁）显著高于良性或瘤样病变患者（p<0.01）。 结论：手部肿瘤以良性及瘤样病变为主，恶性肿瘤虽少见但具有重要临床意义。手术切除仍是主要治疗方式，需结合术前影像学评估并经组织病理学确诊。扩大病例队列并整合分子诊断与患者报告结局，可能有助于优化未来的治疗策略。
肿瘤(癌症)患者之家