Background: The prognosis for recurrent ovarian cancer is poor, but a small percentage of patients can be cured. The aim of this study was to clarify the criteria for being cured and the characteristics of cured cases. Methods: Ovarian cancer cases at 2 university hospitals and 8 community hospitals were analyzed to identify patients who were considered cured after complete remission (CR) following recurrence. Analyses of the tumors were performed and includedBRCA1/2mutation analysis. Results: Of the 157 cases of recurrence, 21 (13%) showed no evidence of disease (NED). NED cases had a lower rate of ascites at the initial diagnosis, longer disease-free survival, a higher rate of solitary lesions, and a higher rate of secondary debulking surgery. All CR cases except for one showed no further recurrence when DFS reached 4 years, which was considered a criterion for being cured. The case of relapse occurred after long-term treatment with bevacizumab. Furthermore, 19.4% of the CR cases achieved 4-year DFS, which represents 9.3% of the cases of recurrent ovarian cancer and 2.3% of all cases of ovarian cancer.BRCAmutation analysis of the tumor was possible in 17 of the 30 cases of recurrent ovarian cancer that achieved a 4-year DFS. Pathogenic variants ofBRCAwere found in 5 of the 11 cases of high-grade serous carcinoma. Conclusions: Approximately 10% of patients with recurrent ovarian cancer achieved a 4-year DFS and were mostly cured. The curing of cases not involving high-grade serous carcinoma (HGSC) was unrelated to the presence of pathogenicBRCAvariants.
背景：复发性卵巢癌的预后较差，但仍有少数患者可被治愈。本研究旨在明确治愈标准及治愈病例的特征。方法：分析两所大学医院和八所社区医院的卵巢癌病例，筛选出复发后达到完全缓解（CR）且被认为治愈的患者。对肿瘤进行分析，包括BRCA1/2基因突变检测。结果：在157例复发病例中，21例（13%）达到无疾病证据（NED）状态。NED病例在初诊时腹水发生率较低，无病生存期更长，孤立病灶比例更高，二次减瘤手术率更高。除一例外，所有CR病例在无病生存期达到4年后均未出现进一步复发，这被视为治愈标准。唯一复发病例发生在长期使用贝伐珠单抗治疗后。此外，19.4%的CR病例实现了4年无病生存期，占复发性卵巢癌病例的9.3%，占所有卵巢癌病例的2.3%。在30例达到4年无病生存期的复发性卵巢癌病例中，有17例成功进行了肿瘤BRCA突变分析。在11例高级别浆液性癌中，有5例发现了致病性BRCA变异。结论：约10%的复发性卵巢癌患者实现了4年无病生存期且大多获得治愈。非高级别浆液性癌（HGSC）病例的治愈与致病性BRCA变异的存在无关。
Cure of Recurrent Ovarian Cancer: A Multicenter Retrospective Study
肿瘤(癌症)患者之家