Background/Objectives: With the growing number of cancer survivors receiving long-term endocrine therapy, understanding its potential effects on oral and periodontal health is of increasing clinical relevance. This systematic review aimed to synthesize current evidence on the impact of hormone therapies used in cancer treatment on periodontal status.Methods: A comprehensive literature search was conducted across the Medline, Web of Science, and Scopus databases to identify observational studies published up to June 2025 that evaluated the effects of endocrine therapy on periodontal parameters and tooth loss in cancer patients.Results: Thirteen studies met the inclusion criteria, twelve involving breast cancer patients and one prostate cancer. Third-generation aromatase inhibitors (AIs) were the most frequently studied agents, either alone or in comparison with tamoxifen. Most studies reported that AI therapy was associated with a higher prevalence of severe periodontitis, increased bleeding on probing and more severe alveolar bone loss compared to healthy controls. In contrast, tamoxifen appeared to have a comparatively milder impact on periodontal health. The single study on prostate cancer patients undergoing androgen deprivation therapy similarly indicated a higher prevalence of periodontitis with respect to controls.Conclusions: These findings suggest a potential link between endocrine therapy and periodontal status deterioration, particularly with AIs. This review highlights an important yet often neglected aspect of survivorship care and emphasizes the need for routine periodontal assessment and interdisciplinary collaboration in the management of patients undergoing hormone therapy for cancer.
背景/目的：随着接受长期内分泌治疗的癌症幸存者数量不断增加，理解其对口腔及牙周健康的潜在影响具有日益重要的临床意义。本系统综述旨在综合当前关于癌症治疗中使用的激素疗法对牙周状况影响的证据。 方法：通过系统检索Medline、Web of Science和Scopus数据库，纳入截至2025年6月发表的观察性研究，评估内分泌治疗对癌症患者牙周参数及牙齿丧失的影响。 结果：共纳入13项研究，其中12项涉及乳腺癌患者，1项涉及前列腺癌患者。第三代芳香化酶抑制剂是最常研究的药物，包括单独使用或与他莫昔芬对比。多数研究表明，与健康对照组相比，芳香化酶抑制剂治疗与重度牙周炎患病率升高、探诊出血增加及更严重的牙槽骨丧失相关。相比之下，他莫昔芬对牙周健康的影响相对较轻。唯一针对前列腺癌患者接受雄激素剥夺治疗的研究同样显示，其牙周炎患病率高于对照组。 结论：这些发现提示内分泌治疗（尤其是芳香化酶抑制剂）可能与牙周状况恶化存在潜在关联。本综述揭示了癌症幸存者照护中一个重要但常被忽视的方面，并强调在接受激素治疗的癌症患者管理中，需要常规进行牙周评估并加强多学科协作。
Impact of Endocrine Therapy for Cancer on Periodontal Health: A Systematic Review
肿瘤(癌症)患者之家