文章：

整合素信号在黑色素瘤细胞中的治疗应用：与细胞外基质（ECM）的物理连接

Therapeutic Use of Integrin Signaling in Melanoma Cells: Physical Link with the Extracellular Matrix (ECM)

原文发布日期：17 September 2025

DOI: 10.3390/cancers17183037

类型: Article

开放获取: 是

英文摘要：

Extracellular matrix (ECM) macromolecules play a vital role in the regulation of cellular phenotype. Ongoing interactions of the extracellular matrix and cells via surface receptors can affect the cellular behavior selectively or non-selectively. Under physiological conditions, the ECM-cell interactions are essential for ensuring balance, whereas the dysregulation of these interactions can lead to the onset of diseases. Extensive knowledge of the integrins with two non-covalently linked α and β subunits plays a vital role in cell–cell adhesion and ECM interactions. The identification of a key adhesion signaling pathway may lead to new therapeutic strategies targeting melanoma cells. This review highlights the potential role of integrins as a selective target in melanoma therapy, which would reduce side effects and increase the effects of the treatment.

摘要翻译： 

细胞外基质大分子在调控细胞表型中扮演着关键角色。细胞外基质通过表面受体与细胞持续进行的相互作用，能够选择性地或非选择性地影响细胞行为。在生理条件下，细胞外基质与细胞的相互作用对于维持机体平衡至关重要，而这些相互作用的失调则可能导致疾病的发生。整合素作为由α和β亚基非共价结合形成的跨膜蛋白，在细胞间黏附及细胞外基质相互作用中具有重要作用。对关键黏附信号通路的识别可能为针对黑色素瘤细胞的新型治疗策略开辟道路。本综述重点探讨了整合素作为黑色素瘤治疗选择性靶点的潜在价值，这种靶向治疗有望减少副作用并提升治疗效果。

原文链接：

Therapeutic Use of Integrin Signaling in Melanoma Cells: Physical Link with the Extracellular Matrix (ECM)