Background/Objectives: The individual and combined effects of diverse dental problems on site-specific respiratory tract cancer remain insufficiently addressed. This study investigated the associations between six oral conditions—dentures, loose teeth, painful gums, bleeding gums, toothache, and mouth ulcers—and the risk of developing cancers of the lung, bronchus, larynx, and trachea, both individually and collectively. Methods: This prospective cohort study, utilizing baseline data from the UK Biobank, analyzed 438,762 participants aged 40–69 years. Multivariable Cox proportional hazards models were employed to estimate hazard ratios (HRs) and 95% CIs for incident respiratory tract cancer associated with individual oral conditions and their cumulative impact. Effect modification by sociodemographics, lifestyle, and underlying medical conditions was further assessed. Results: During the follow-up (median = 11.0 years), 3568 participants developed respiratory tract cancer. After adjusting for confounders, including smoking history, individuals with any oral issues exhibited a 35–76% higher risk of respiratory tract cancer (HR [95% CI]: 1.35 [1.25–1.46] for the total risk, 1.34 [1.24–1.45] for bronchus/lung cancer, and 1.76 [1.23–2.52] for laryngeal cancer). Dentures (1.48 [1.36–1.60]), loose teeth (1.36 [1.20–1.54]), and painful gums (1.25 [1.04–1.50]) had a strong association with respiratory tract cancer. The overall risk escalated progressively with the number of concurrent problems (HR [95% CI] of 1.32 [1.22–1.43] for one, 1.42 [1.25–1.62] for two, 1.57 [1.23–1.98] for three, and 1.71 [1.16–2.50] for ≥four). Associations were pronounced among smokers (p-interaction = 0.002). Conclusions: Poor oral health is linked to a heightened risk of respiratory tract cancer, especially when coupled with smoking, underscoring the importance of oral health promotion in cancer prevention strategies.
背景/目的：各类口腔问题对特定部位呼吸道癌症的单独及联合影响尚未得到充分探讨。本研究调查了六种口腔状况——假牙、牙齿松动、牙龈疼痛、牙龈出血、牙痛和口腔溃疡——与肺、支气管、喉及气管癌症发病风险的单独及联合关联。方法：这项前瞻性队列研究利用英国生物银行的基线数据，分析了438,762名年龄在40-69岁之间的参与者。采用多变量Cox比例风险模型评估了与个体口腔状况及其累积影响相关的呼吸道癌症发病风险比（HR）和95%置信区间（CI）。进一步评估了社会人口学特征、生活方式和基础疾病对效应的影响。结果：在随访期间（中位时间=11.0年），共有3568名参与者罹患呼吸道癌症。在调整包括吸烟史在内的混杂因素后，存在任何口腔问题的个体患呼吸道癌症的风险高出35–76%（总风险HR [95% CI]: 1.35 [1.25–1.46]，支气管/肺癌风险: 1.34 [1.24–1.45]，喉癌风险: 1.76 [1.23–2.52]）。假牙（1.48 [1.36–1.60]）、牙齿松动（1.36 [1.20–1.54]）和牙龈疼痛（1.25 [1.04–1.50]）与呼吸道癌症有显著关联。总体风险随着并发问题数量的增加而逐步上升（一个问题的HR [95% CI]为1.32 [1.22–1.43]，两个为1.42 [1.25–1.62]，三个为1.57 [1.23–1.98]，四个及以上为1.71 [1.16–2.50]）。这种关联在吸烟者中尤为明显（交互作用p值=0.002）。结论：口腔健康状况不佳与呼吸道癌症风险升高相关，尤其是在吸烟的情况下，这凸显了在癌症预防策略中促进口腔健康的重要性。
肿瘤(癌症)患者之家