While nutrition is often considered a protective factor against cancer, there is a scarcity of strong, conclusive evidence supporting its direct impact on cervical cancer (CC) prevention. This study aims to review the existing literature on the relationship between women’s nutrition and infection by the human papillomavirus (HPV) and the development of CC. It explores the key nutrients, foods, and dietary patterns that may influence the onset and progression of this disease, including research carried out in sub-Saharan Africa, other low-income countries, and worldwide. The review process revealed that, despite the large initial pool of articles, the majority were excluded because they were not focused on nutrition and CC. However, the articles that met the inclusion criteria suggested an association between diet and lower susceptibility to persistent HPV infections, which could progress into cervical lesions or cancer. Notably, lower folate intake was associated with up to a nine-fold higher risk of CIN3+ lesions (OR 8.9, 95% CI 3.4–24.9), while increased consumption of certain vitamins and antioxidant-rich foods consistently correlated with lower HPV persistence and progression. These results could indicate that consuming antioxidant compounds, certain vitamins, dietary patterns, and functional foods may offer protective benefits against developing this disease and its progression. By emphasizing nutrition as a modifiable factor, this review seeks to raise awareness and propose a holistic approach to CC prevention—integrating public health, dietary considerations, and equity-driven strategies.
尽管营养常被视为癌症的防护因素，但目前仍缺乏有力且确凿的证据支持其对宫颈癌预防的直接作用。本研究旨在系统回顾现有文献中关于女性营养状况与人乳头瘤病毒感染及宫颈癌发生发展关系的相关研究，重点探讨可能影响该疾病发生与进展的关键营养素、食物及膳食模式，涵盖撒哈拉以南非洲地区、其他低收入国家及全球范围内的相关研究。文献筛选过程显示，尽管初始文献数量庞大，但多数因未聚焦营养与宫颈癌主题而被排除。符合纳入标准的研究表明，膳食因素与降低持续性HPV感染风险存在关联，而持续性感染可能进展为宫颈病变或癌症。值得注意的是，叶酸摄入量不足与宫颈上皮内瘤变3级及以上病变风险升高达九倍相关（OR 8.9，95% CI 3.4–24.9），而特定维生素及富含抗氧化剂食物的摄入增加则持续与HPV持续感染及疾病进展风险降低相关。这些结果提示，摄入抗氧化成分、特定维生素、特定膳食模式及功能性食品可能对预防宫颈癌发生发展具有保护作用。通过强调营养作为可调控因素，本综述旨在提升公众认知，并提出整合公共卫生、膳食干预及公平性策略的宫颈癌综合预防方案。
肿瘤(癌症)患者之家