文章：

表现为磨玻璃影的肺腺癌的临床病理特征及预后：单中心经验

Clinicopathological Features and Prognosis of Lung Adenocarcinoma Presenting as Ground-Glass Opacity: A Single-Center Experience

原文发布日期：16 September 2025

DOI: 10.3390/cancers17183016

类型: Article

开放获取: 是

英文摘要：

Objectives: Adenocarcinoma presenting as ground-glass opacities (GGOs) often corresponds to lepidic growth tumor and is associated with less invasive behavior and a good prognosis. The aim of this study is to investigate the correlation between radiological and pathological findings of GGO and their relationship with lung cancer-specific survival (LCSS) and incidence of relapses to better define their surgical management.Methods: One hundred seventy-two patients underwent lung resection for adenocarcinoma presenting as pure GGO or partial solid GGO at CT scan. Based on consolidation-to-tumor ratio (CTR) at CT scan, patients were categorized into two groups: pure GGO (CTR 0) and partial solid GGO (CTR ≤ 0.5, 0.5 < CTR ≤ 0.75, and 0.75 < CTR ≤ 1.0). Histological analysis confirmed diagnosis, invasiveness, and grading.Results: Comparing the group with pure GGO (n = 90; 52.3%) and the groups with partial solid GGO (n = 82; 47.7%), invasive adenocarcinoma was significantly more frequent in the last one (p= 0.0006). In the partial solid GGO group, the majority of tumors were G2, and the percentage of G3 tumors increased with the CTR increasing (p< 0.0001). Twenty-one (12.2%) patients experienced disease recurrence: 16 (9.3%) were invasive adenocarcinoma (IA), and 5 (2.9%) were minimally invasive adenocarcinomas (MIA); radiologically, 13 (7.5%) were pure GGO, and 8 (4.6%) had a solid component. At multivariate analysis, relapse was associated with age > 60 (p= 0.037), clinical stage ≥ cIB (p= 0.002), and sublobar resection (p= 0.005).Conclusions:Pure GGO was associated with minor invasiveness, with prognosis dependent on age, clinical stage, and type of surgery (sublobar vs. lobar resection). Sublobar resections had a higher recurrence risk.

摘要翻译： 

目的：表现为磨玻璃影（GGO）的腺癌通常对应附壁生长型肿瘤，其侵袭性较低且预后良好。本研究旨在探讨GGO的影像学与病理学特征之间的相关性，及其与肺癌特异性生存期（LCSS）和复发率的关系，以进一步明确其手术管理策略。 方法：172例CT扫描表现为纯磨玻璃影或部分实性磨玻璃影的腺癌患者接受了肺切除术。根据CT扫描的实性成分占比（CTR），患者被分为两组：纯磨玻璃影组（CTR=0）和部分实性磨玻璃影组（CTR≤0.5、0.560岁（p=0.037）、临床分期≥cIB期（p=0.002）以及亚肺叶切除术（p=0.005）相关。 结论：纯磨玻璃影与较低的侵袭性相关，其预后取决于年龄、临床分期和手术类型（亚肺叶切除与肺叶切除）。亚肺叶切除术具有较高的复发风险。

原文链接：

Clinicopathological Features and Prognosis of Lung Adenocarcinoma Presenting as Ground-Glass Opacity: A Single-Center Experience