Background: Previous studies have found that the presence and density of tumor-infiltrating T lymphocytes has significant prognostic value in colon and rectal cancer. However, there is a paucity of systematic reviews focusing on the role of tumor-infiltrating B lymphocytes (TIBLs) in colorectal cancer. The aim of this review was to assess the role of all known subsets of TIBLs implicated in colorectal cancer, as well as to identify the methodologies used for the identification of TIBLs and establish their prognostic value in the colorectal tumor microenvironment (TME). Methods: A systematic literature search was conducted from 2000 to 2025 using the PubMed (Medline), Embase and Cochrane Library databases. Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines were followed to identify eligible studies. Results: A total of 32 original papers involving 5766 individual patients met the inclusion criteria. Several B cell types in the immune TME of colon and rectal cancer were identified, each with specific roles and prognostic value. Several distinct methodologies were used for the identification of these cells, according to specific detection protocols used by various institutions. Certain immunological pathways through which these cells may be involved in the carcinogenesis of colorectal tumors have also been identified, which may potentially lead to the development of novel immunotherapy targets. Conclusions: We concluded that TIBLs play a significant role in the immune microenvironment of colorectal cancer, providing theoretical evidence for potential biomarkers which may constitute a valuable target for individualized treatment.
背景：既往研究发现，肿瘤浸润T淋巴细胞的存在及密度在结肠癌和直肠癌中具有显著预后价值。然而，目前缺乏针对肿瘤浸润B淋巴细胞（TIBLs）在结直肠癌中作用的系统性综述。本综述旨在评估所有已知TIBLs亚群在结直肠癌中的作用，梳理TIBLs的鉴定方法，并明确其在结直肠肿瘤微环境（TME）中的预后价值。 方法：通过PubMed（Medline）、Embase和Cochrane图书馆数据库对2000年至2025年的文献进行系统性检索。遵循系统综述与荟萃分析优先报告条目（PRISMA）指南筛选符合条件的研究。 结果：共纳入32篇原始研究，涉及5766例患者。研究明确了结肠癌和直肠癌免疫TME中多种B细胞类型，每种细胞均具有特定功能及预后价值。不同机构根据特定检测方案采用了多种鉴定方法。同时研究揭示了这些细胞可能参与结直肠肿瘤发生的特定免疫通路，这有望为开发新型免疫治疗靶点提供方向。 结论：TIBLs在结直肠癌免疫微环境中发挥重要作用，为潜在生物标志物提供了理论依据，这些标志物可能成为个体化治疗的重要靶点。
肿瘤(癌症)患者之家