The connection between NK cells and cancer offers valuable insights into disease management. Suppressing NK cells can encourage cancer growth, while cancer itself can weaken NK cell function. This review examines how genetic and environmental factors such as diet affect NK cell numbers and function during the early stages of cancer. It also explores the reduced NK cell activity in cancer-bearing mouse models and human patients. The mechanisms behind cytotoxic actions and cytokine release are analyzed across four NK cell maturation stages. This understanding highlights the potential of using healthy donor NK cells for immunotherapy, alongside the role of memory NK cells in treatments. While NK cell-based therapies show promise in studies, challenges remain in sustaining their effectiveness and durability. This review also discusses strategies to improve production and boost the efficiency of donor NK cell therapies.
自然杀伤细胞（NK细胞）与癌症之间的关联为疾病管理提供了重要见解。抑制NK细胞可促进癌症发展，而癌症本身亦会削弱NK细胞功能。本综述探讨了在癌症早期阶段，遗传因素及饮食等环境因素如何影响NK细胞数量与功能，同时分析了荷瘤小鼠模型及人类患者中NK细胞活性降低的现象。研究通过四个NK细胞成熟阶段，系统解析了其细胞毒性作用与细胞因子释放的内在机制。这一认识凸显了利用健康供体NK细胞进行免疫治疗的潜力，以及记忆性NK细胞在治疗中的作用。尽管基于NK细胞的疗法在研究中展现出前景，但其疗效持久性仍面临挑战。本综述还讨论了提升供体NK细胞疗法生产效率与疗效的策略。
肿瘤(癌症)患者之家