文章：

单细胞RNA测序在揭示皮肤T细胞淋巴瘤疾病机制中的最新进展

An Update on Single-Cell RNA Sequencing in Illuminating Disease Mechanisms of Cutaneous T-Cell Lymphoma

原文发布日期：5 September 2025

DOI: 10.3390/cancers17172921

类型: Article

开放获取: 是

英文摘要：

Cutaneous T-cell Lymphomas (CTCLs) are a heterogeneous group of non-Hodgkin lymphomas that currently have an incompletely understood pathophysiology and several challenges in both diagnosis and management. Single-cell RNA sequencing (scRNA-seq) is a powerful tool that enables the analysis of gene expression at the individual-cell level, revealing cellular heterogeneity and a complex tumor microenvironment. As single-cell RNA sequencing has become increasingly utilized, we aimed to provide an update on recent notable applications of single-cell RNA sequencing in CTCL and their findings. The included studies highlight the intricate network of interactions in the tumor microenvironment that contributes to tumorigenesis. While CTCL is notoriously heterogeneous, our results identify key markers that prove promising for diagnosis, prognostication, and therapeutic targets.

摘要翻译： 

皮肤T细胞淋巴瘤（CTCL）是一组异质性的非霍奇金淋巴瘤，目前其病理生理机制尚未完全明确，在诊断和治疗方面均面临诸多挑战。单细胞RNA测序（scRNA-seq）作为一种强大的技术工具，能够在单细胞水平分析基因表达，揭示细胞异质性及复杂的肿瘤微环境。随着单细胞RNA测序技术的日益普及，本文旨在综述该技术在CTCL研究中的最新重要应用及其发现。相关研究揭示了肿瘤微环境中促进肿瘤发生的复杂相互作用网络。尽管CTCL具有显著的异质性，但我们的研究结果识别出对诊断、预后评估及治疗靶点具有重要价值的关键标志物。

原文链接：

An Update on Single-Cell RNA Sequencing in Illuminating Disease Mechanisms of Cutaneous T-Cell Lymphoma