Background/Objectives: Human papillomavirus (HPV) is a known etiologic agent in oropharyngeal cancers, but its role in oral cavity squamous cell carcinoma (OCSCC) remains unclear. This systematic review and meta-analysis aimed to estimate the global prevalence of HPV in OCSCC and explore variation by clinicodemographic and tumor characteristics.Methods:We systematically searched multiple databases for studies reporting HPV prevalence in OCSCC. Pooled prevalence estimates were calculated, and subgroup analyses examined differences by age, gender, cancer stage, anatomical site, histologic subtype, region, and HPV type (HPV-16 and HPV-18). Heterogeneity and publication bias were assessed using standard meta-analytic techniques.Results:A total of 122 studies involving 16,311 patients were included. The pooled HPV prevalence in OCSCC was 25.8% (95% CI: 20.4–31.2), with HPV-16 and HPV-18 detected in 52.4% and 30.3% of positive cases, respectively. Prevalence varied geographically, from 73% in Singapore to 7.7% in South Korea. Younger patients (<40 years) had higher HPV positivity (29.7%) than older patients (>70 years, 23.8%). Early-stage cancers (stage I) showed higher HPV prevalence (41.8%) than advanced-stage cancers (stage IV, 10.4%). Verrucous carcinoma had the highest HPV positivity (34.1%), and moderately differentiated tumors the lowest (23.4%). HPV prevalence was highest in the lower alveolus (29.5%) and lips (25%), and lowest in the upper gingiva (3.9%).Conclusions:HPV prevalence in OCSCC demonstrates significant heterogeneity across regions and clinical subgroups. These findings emphasize the need for standardized diagnostic approaches and further research into the role of HPV in OCSCC pathogenesis and treatment.
背景/目的：人乳头瘤病毒（HPV）是口咽癌的已知致病因子，但其在口腔鳞状细胞癌（OCSCC）中的作用尚不明确。本系统综述与荟萃分析旨在评估全球OCSCC中HPV的流行率，并探讨其与临床人口学特征及肿瘤特性的关联差异。 方法：我们系统检索了多个数据库中报告OCSCC HPV流行率的研究。计算汇总流行率估计值，并通过亚组分析考察年龄、性别、癌症分期、解剖部位、组织学亚型、地域及HPV类型（HPV-16与HPV-18）的差异。采用标准荟萃分析技术评估异质性与发表偏倚。 结果：共纳入122项研究，涉及16,311例患者。OCSCC中HPV汇总流行率为25.8%（95% CI: 20.4–31.2），其中HPV-16与HPV-18在阳性病例中的检出率分别为52.4%与30.3%。流行率存在地域差异，从新加坡的73%至韩国的7.7%不等。年轻患者（<40岁）HPV阳性率（29.7%）高于老年患者（>70岁，23.8%）。早期癌症（I期）的HPV流行率（41.8%）高于晚期癌症（IV期，10.4%）。疣状癌的HPV阳性率最高（34.1%），中分化肿瘤最低（23.4%）。下牙槽区（29.5%）与唇部（25%）HPV流行率最高，上牙龈区最低（3.9%）。 结论：OCSCC中HPV流行率在不同地域与临床亚组间存在显著异质性。这些发现强调需要建立标准化诊断方法，并进一步研究HPV在OCSCC发病机制与治疗中的作用。
肿瘤(癌症)患者之家