Malignant genitourinary tumors have demonstrated a rising incidence and are characterized by significant morbidity and mortality. Advances in sequencing technologies have greatly enhanced our understanding of the genetic and molecular mechanisms that drive tumor biology. In recent years, spatial transcriptomics technologies have rapidly evolved, enabling precise quantification and visualization of gene expression within the spatial context of tissues. Unlike conventional transcriptomics, which focuses on gene expression levels, spatial transcriptomics provides additional insights into the spatial distribution of genes within tissues, cellular composition, and cell-to-cell interactions within biological samples. In this narrative review, we outline the emerging role and future potential of spatial transcriptomics technology in genitourinary cancers.
恶性泌尿生殖系统肿瘤的发病率呈上升趋势，且具有较高的发病率和死亡率。测序技术的进步极大地增进了我们对驱动肿瘤生物学的遗传和分子机制的理解。近年来，空间转录组学技术迅速发展，能够在组织空间背景下对基因表达进行精确量化和可视化。与仅关注基因表达水平的传统转录组学不同，空间转录组学进一步揭示了生物样本中基因在组织内的空间分布、细胞组成以及细胞间的相互作用。本文通过叙述性综述，概述了空间转录组学技术在泌尿生殖系统癌症中的新兴作用及未来潜力。
Current Role and Future Frontiers of Spatial Transcriptomics in Genitourinary Cancers
肿瘤(癌症)患者之家