Background/Objectives:The burden of early-onset cancer (cancer incidence <50 years) has increased globally. Early-onset cancer carries significant societal and economic consequences. We aim to provide updated estimates for incidence and mortality of early-onset cancer.Methods:We analyzed the Global Burden of Disease Study 2021 to describe the incidence, death, age-standardized incidence rate (ASIR), age-standardized death rate (ASDR) from early-onset cancer (i.e., cancer in people aged 15–49), and its changes from 2000 to 2021 (reflected as annual percent change [APC]), using Joinpoint regression analysis.Results:In 2021, there were 3.16 million new cases and 989,650 deaths from early-onset cancer. From 2000 to 2021, the ASIR of early-onset cancer increased (APC: 0.40%, 95% CI 0.32 to 0.47%), with the highest increase observed in the Eastern Mediterranean region (APC: 1.63%, 95% CI 1.53 to 1.72%), whereas the ASDR decreased across most regions. The ASIR for early-onset cancer had a higher increase in females (APC: 0.62%, 95% CI 0.51 to 0.73%) than males (APC: 0.14%, 95% CI 0.04 to 0.23%). Breast cancer (n= 567,900) constituted the highest burden of incident cases, followed by non-melanoma skin (n= 507,810) and cervical cancers (n = 307,430). The highest increase in the ASIR was observed in non-melanoma skin cancer (APC:2.18%, 95% CI 1.85–2.51%), thyroid (APC: 1.70%, 95% CI 1.60 to 1.79%), and testicular (APC:1.37%, 95% CI 0.96 to 1.78%) cancers. The greatest increases in the ASDR were observed in peripheral nervous system cancer (APC: 0.97%, 95% CI 0.82 to 1.11%) and multiple myeloma (APC: 0.62%, 95% CI 0.51 to 0.72%).Conclusions:From 2000 to 2021, the age-adjusted incidence of early-onset cancer increased, with variation across regions and cancer types. Immediate measures are required at a global, regional, and national level to mitigate the burden of early-onset cancer.
**背景/目的：** 早发性癌症（发病年龄<50岁）的负担在全球范围内持续加重，对社会与经济造成显著影响。本研究旨在提供早发性癌症发病率与死亡率的最新评估数据。 **方法：** 基于2021年全球疾病负担研究数据，我们采用Joinpoint回归分析，描述了2000年至2021年间早发性癌症（即15–49岁人群）的发病数、死亡数、年龄标准化发病率（ASIR）、年龄标准化死亡率（ASDR）及其变化趋势（以年度百分比变化[APC]表示）。 **结果：** 2021年，全球早发性癌症新发病例为316万例，死亡病例为989,650例。2000年至2021年间，早发性癌症的ASIR呈上升趋势（APC：0.40%，95% CI 0.32–0.47%），其中东地中海地区增幅最大（APC：1.63%，95% CI 1.53–1.72%），而大多数地区的ASDR呈下降趋势。女性早发性癌症的ASIR增幅（APC：0.62%，95% CI 0.51–0.73%）高于男性（APC：0.14%，95% CI 0.04–0.23%）。乳腺癌（n=567,900）的发病负担最高，其次为非黑色素瘤皮肤癌（n=507,810）和宫颈癌（n=307,430）。ASIR增幅最高的癌症类型为非黑色素瘤皮肤癌（APC：2.18%，95% CI 1.85–2.51%）、甲状腺癌（APC：1.70%，95% CI 1.60–1.79%）和睾丸癌（APC：1.37%，95% CI 0.96–1.78%）。ASDR增幅最高的为周围神经系统肿瘤（APC：0.97%，95% CI 0.82–1.11%）和多发性骨髓瘤（APC：0.62%，95% CI 0.51–0.72%）。 **结论：** 2000年至2021年间，早发性癌症的年龄标准化发病率呈上升趋势，且存在地区与癌症类型的差异。亟需在全球、区域和国家层面采取即时措施，以减轻早发性癌症带来的负担。
Contemporary Changes in Global Trends in Early-Onset Cancer: Incidence and Mortality (2000–2021)
肿瘤(癌症)患者之家