文章：

定义直肠癌盆腔廓清术标准数据报告：PelvEx协作组对当前数据报告的综述

Defining Standard Data Reporting in Pelvic Exenteration Surgery for Rectal Cancer: A PelvEx Collaborative Review of Current Data Reporting

原文发布日期：25 August 2025

DOI: 10.3390/cancers17172764

类型: Article

开放获取: 是

英文摘要：

Introduction: Pelvic exenteration (PEx) is a radical procedure used in the treatment of locally advanced (LARC) and locally recurrent rectal cancer (LRRC). With recent advancements in perioperative treatment regimens, there has been renewed interest in this procedure as it offers the opportunity for complete tumour resection in a select cohort. This has resulted in large heterogeneity in outcome reporting, making comparing and conducting a meta-analysis of published results challenging. Standardising outcome reporting will ensure meaningful data reporting and allow the cross-centre comparison of data. Aims: To conduct a systematic review of the current literature, to identify the various outcomes reported for PEx in rectal cancer, and to develop a standard outcome reporting set. Methods: A systematic review was carried out following the PRISMA guidelines. Relevant domains were identified first. Data elements (DEs) were extracted verbatim prior to standardisation and mapping to relevant domains. Results: There has been a noticeable trend of increased literature on PEx in the last decade. Forty-nine papers were identified. A total of 1549 DEs were extracted verbatim. These were standardised to 119 unique DEs mapped to ten distinct domains capturing the patient care journey. There was large variation in the frequency of reporting, with some key outcomes reported in a limited number of studies. Conclusions: There is considerable heterogeneity at present in data reporting for PEx in LARC and LRRC. Standardisation of outcomes is the first step in guiding the development of a core information set to overcome heterogeneity and guide future research development.

摘要翻译： 

引言：盆腔廓清术（PEx）是治疗局部进展期直肠癌（LARC）和局部复发直肠癌（LRRC）的一种根治性手术。随着围手术期治疗方案的近期进展，该术式因能为特定患者群体提供肿瘤完全切除的机会而重新受到关注。这导致疗效报告存在显著异质性，使得对已发表结果进行比较和开展荟萃分析具有挑战性。标准化结果报告将确保数据报告的有效性，并实现跨中心数据比较。 目的：通过系统综述现有文献，明确直肠癌PEx手术中报告的各种疗效指标，并建立标准化结果报告集。 方法：按照PRISMA指南进行系统综述。首先确定相关领域，在标准化和映射至对应领域前逐字提取数据要素。 结果：近十年来关于PEx的文献呈现显著增长趋势。共纳入49篇文献，提取1549个原始数据要素，经标准化处理后归纳为119个独立数据要素，映射至涵盖患者诊疗全过程的十个核心领域。各指标报告频率差异显著，部分关键结局指标仅在有限研究中被报道。 结论：当前LARC和LRRC的PEx数据报告存在显著异质性。结果标准化是构建核心信息集以克服异质性、指导未来研究发展的首要步骤。

原文链接：

Defining Standard Data Reporting in Pelvic Exenteration Surgery for Rectal Cancer: A PelvEx Collaborative Review of Current Data Reporting