文章：

口腔微生物组与头颈癌：一篇叙述性综述

The Oral Microbiome and Head and Neck Cancer: A Narrative Review

原文发布日期：23 August 2025

DOI: 10.3390/cancers17172736

类型: Article

开放获取: 是

英文摘要：

In recent years, a growing body of evidence points to a link between alterations in the oral microbiome and the development and progression of head and neck cancer (HNC). At present, however, this highly complex relationship is only partially understood. In this context, there is a clear need to characterise and differentiate microbial profiles in patients with and without HNC to identify risk factors, prognostic biomarkers, and potential therapeutic targets. In the present narrative review, we synthesize the current evidence on the role of oral dysbiosis in HNC, with a particular focus on potential biomarkers and novel treatment and prevention strategies.

摘要翻译： 

近年来，越来越多的证据表明口腔微生物组的改变与头颈癌的发生发展存在关联。然而，目前对这种高度复杂关系的认识尚不全面。在此背景下，明确区分头颈癌患者与非患者的微生物特征，对于识别风险因素、预后生物标志物及潜在治疗靶点具有迫切需求。本综述整合了当前关于口腔菌群失调在头颈癌中作用的研究证据，重点关注潜在的生物标志物以及新型治疗与预防策略。

原文链接：

The Oral Microbiome and Head and Neck Cancer: A Narrative Review