Background/Objectives: Advances in endometrial cancer treatment, such as minimally invasive surgery and the introduction of targeted therapies, could influence survivorship and result in changes in issues experienced by survivors of endometrial cancer. To improve endometrial cancer survivorship, it is first necessary to understand it. Therefore, the purpose of this study was to describe contemporary endometrial cancer survivorship issues.Methods: This study involved an umbrella review and cross-sectional survey of healthcare professionals. The umbrella review involved searching Medline (2013–2023) to identify published reviews describing survivorship outcomes in endometrial cancer survivors. Articles were screened and survivorship outcomes were extracted. Healthcare professionals working with patients diagnosed with endometrial cancer were asked to (1) rate the relevance of each survivorship outcome identified in the review, and (2) list any additional issues considered of clinical relevance.Results: Following the screening of 201 articles (159 papers excluded:n= 1 duplicate;n= 158 ineligible), 42 review articles were included and 25 survivorship outcomes identified including physical health (e.g., fatigue, pain), fertility (e.g., parity), quality of life (e.g., cognitive wellbeing), treatment-related toxicities, and mental health outcomes (e.g., anxiety). The cross-sectional survey was completed by 37 healthcare professionals (two-thirds being medical oncologists or gynaecological oncologists) working across Australia and New Zealand, with outcomes rated as relevant by 30% (for cachexia) to 100% (for body weight/obesity and functional wellbeing of respondents. An additional 28 survivorship issues not identified in the review were reported by healthcare professionals.Conclusions: The current endometrial cancer survivorship literature is limited. The review, together with expert input from healthcare professionals, identified 53 survivorship issues. These findings will now inform development of a survey to explore the frequency, impact, and severity of survivorship issues from the perspective of endometrial cancer survivors, the results of which will guide the provision of supportive cancer care, in addition to guiding research and clinical practice.
背景/目的：子宫内膜癌治疗手段的进步，如微创手术和靶向疗法的引入，可能影响患者生存状况，并导致子宫内膜癌幸存者面临的问题发生变化。为改善子宫内膜癌患者的生存质量，首先需要全面了解其生存现状。因此，本研究旨在系统描述当代子宫内膜癌幸存者面临的生存问题。 方法：本研究采用伞状综述与横断面调查相结合的方法，对医疗专业人员进行调研。伞状综述通过检索Medline数据库（2013-2023年）筛选描述子宫内膜癌幸存者生存结局的已发表综述文献，经系统筛选后提取生存结局指标。同时，邀请从事子宫内膜癌诊疗的医疗专业人员完成两项任务：（1）对综述中识别的各项生存结局指标进行临床相关性评分；（2）补充列出具有临床重要性的其他问题。 结果：经对201篇文献进行筛选（排除159篇：重复文献1篇，不符合纳入标准158篇），最终纳入42篇综述，识别出25项生存结局指标，涵盖身体健康（如疲劳、疼痛）、生育状况（如产次）、生活质量（如认知健康）、治疗相关毒性及心理健康（如焦虑）等领域。横断面调查共收集澳大利亚和新西兰地区37名医疗专业人员（其中三分之二为肿瘤内科或妇科肿瘤专科医师）的反馈，各项结局指标的相关性评分介于30%（恶病质）至100%（体重/肥胖及功能健康）之间。此外，医疗专业人员补充报告了28项未在综述中识别的生存问题。 结论：当前子宫内膜癌生存研究文献仍存在局限。通过系统综述结合医疗专业人员的专家意见，本研究共识别出53项生存问题。这些发现将为后续开发调查工具提供依据，从幸存者视角探究各类生存问题的发生频率、影响程度及严重性。相关结果不仅能为支持性癌症照护服务提供指导，还将为未来研究方向和临床实践提供重要参考。
肿瘤(癌症)患者之家