文章：

COVID-19对子宫内膜癌分期与治疗的影响：一项来自意大利综合癌症中心的癌症登记数据分析

Impact of COVID-19 on the Stage and Treatment of Endometrial Cancer: A Cancer Registry Analysis from an Italian Comprehensive Cancer Center

原文发布日期：18 August 2025

DOI: 10.3390/cancers17162686

类型: Article

开放获取: 是

英文摘要：

Background/Objectives: The COVID-19 pandemic has impacted cancer diagnosis and treatment. This study assessed the effects of the pandemic on the stage and delays between diagnosis and treatment in endometrial cancer.Methods: The study included 543 cases diagnosed between 2017 and 2023 in a population-based cancer registry. Data on stage, diagnostic procedures, treatments, and time to surgery (TTS) were compared across the pre-COVID (2017—2019), COVID (2020—2022), and post-COVID (2023) periods. Multiple regression analysis was used to identify factors influencing TTS.Results: During the three periods, stages I and II showed no variation, whereas a significant increase was recorded in stage III (7.5%, 9.5%, and 17.8%, respectively;p< 0.05), as well as a slight increase in grade 3 (15.4%, 13.6%, and 19.2%, respectively). A significant decrease in laparotomies (30.3%, 11.6%, and 11.0%, respectively;p< 0.01) and an increase in laparoscopies (60.1%, 78.1%, and 80.8%, respectively;p< 0.05) were observed. TTS decreased for interventions performed within 30 days (10.1%, 3.7%, and 1.4%, respectively;p< 0.01) and within 60 days (38.6%, 19.4%, and 6.9%, respectively;p< 0.01), while a significant increase was observed for >60 days (22.8%, 29.8%, and 37.0%, respectively;p< 0.05) and >90 days (7.5%, 23.1%, and 20.5%, respectively;p< 0.01). Multivariable analysis confirmed a reduction in TTS in the pre-COVID period (β −19.63; CI 95% −31.31; −7.95) and an increase in the post-COVID period (β 31.60; CI 95% 13.68; 49.53); while an increase was confirmed only for stage IV (β 48.80; CI 95% 23.15; 74.45).Conclusions: The COVID-19 pandemic has led to an increase in more advanced cancers and delays in surgery.

摘要翻译： 

背景/目的：COVID-19大流行对癌症诊断与治疗产生了影响。本研究评估了疫情对子宫内膜癌分期及诊断至治疗延迟时间的影响。 方法：本研究基于人群癌症登记数据，纳入2017年至2023年间确诊的543例病例。比较疫情前（2017-2019年）、疫情期间（2020-2022年）及疫情后（2023年）三个时期的分期、诊断方法、治疗方案及手术等待时间（TTS）数据，并采用多元回归分析探讨影响TTS的因素。 结果：三个研究期间，Ⅰ期和Ⅱ期病例比例无显著变化，而Ⅲ期病例显著增加（分别为7.5%、9.5%和17.8%；p<0.05），3级肿瘤比例亦略有上升（分别为15.4%、13.6%和19.2%）。开腹手术比例显著下降（分别为30.3%、11.6%和11.0%；p<0.01），腹腔镜手术比例显著上升（分别为60.1%、78.1%和80.8%；p<0.05）。30天内实施手术的比例下降（分别为10.1%、3.7%和1.4%；p<0.01），60天内手术比例亦下降（分别为38.6%、19.4%和6.9%；p<0.01）；而手术等待时间超过60天（分别为22.8%、29.8%和37.0%；p<0.05）及超过90天（分别为7.5%、23.1%和20.5%；p<0.01）的病例比例显著增加。多变量分析证实：疫情前时期TTS缩短（β −19.63；95%CI −31.31至−7.95），疫情后时期TTS延长（β 31.60；95%CI 13.68至49.53）；仅Ⅳ期病例的TTS显著延长（β 48.80；95%CI 23.15至74.45）。 结论：COVID-19大流行导致子宫内膜癌晚期病例增加及手术延迟。

原文链接：

Impact of COVID-19 on the Stage and Treatment of Endometrial Cancer: A Cancer Registry Analysis from an Italian Comprehensive Cancer Center