Background/Objectives: The oral microbiome has been implicated in the pathogenesis of head and neck squamous cell carcinoma (HNSCC). This review examines the association between specific oral bacterial taxa and HNSCC.Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to examine the relationship between the oral microbiome and HNSCC. A comprehensive literature search was conducted in databases including EMBASE, Cochrane Library, Web of Science, Medline, and PubMed.Results: Following the screening of 284 articles, 21 studies met the inclusion criteria, comprising 1023 HNSCC patients (male: n = 806, 79%; female: n = 217, 21%) and 837 healthy controls (male: n = 622, 74%; female: n = 215, 25.7%). Although findings on alpha diversity were inconsistent, a significant difference in beta diversity was consistently reported between HNSCC patients and healthy controls. HNSCC patients exhibited higher relative abundances ofFirmicutesandSynergistetesat the phylum level;Fusobacterium,Prevotella,Porphyromonas,Parvimonas, andPeptostreptococcusat the genus level; andFusobacterium nucleatum,Prevotella intermedia,Lactobacillusspp., andPorphyromonas gingivalisat the species level. In contrast, healthy controls showed higher abundances ofProteobacteriaandActinobacteriaat the phylum level;Streptococcus,Actinomyces,Corynebacterium,Rothia, andVeillonellaat the genus level; andHaemophilus influenzae,Rothia mucilaginosa, andStreptococcus mitisat the species level in most studies.Conclusions: The findings indicate distinct alterations in oral microbiome diversity and composition among HNSCC patients, highlighting the role of microbial dysbiosis in cancer progression. Standardized protocols for oral sample collection and microbiota analysis are essential to facilitate more robust, comparable, and clinically meaningful research outcomes.
背景/目的：口腔微生物群与头颈部鳞状细胞癌（HNSCC）的发病机制密切相关。本综述旨在探讨特定口腔细菌类群与HNSCC之间的关联。 方法：遵循系统综述与荟萃分析优先报告项目（PRISMA）指南，对口腔微生物群与HNSCC的关系进行系统综述。在EMBASE、Cochrane Library、Web of Science、Medline和PubMed等数据库中进行了全面的文献检索。 结果：经过对284篇文章的筛选，共纳入21项研究，涵盖1023例HNSCC患者（男性：806例，占79%；女性：217例，占21%）和837例健康对照者（男性：622例，占74%；女性：215例，占25.7%）。尽管α多样性的研究结果存在不一致，但所有研究均一致报道HNSCC患者与健康对照者在β多样性上存在显著差异。在门水平上，HNSCC患者表现出较高丰度的厚壁菌门和协同菌门；在属水平上，梭杆菌属、普雷沃菌属、卟啉单胞菌属、小单胞菌属和消化链球菌属的丰度较高；在种水平上，具核梭杆菌、中间普雷沃菌、乳酸杆菌属和牙龈卟啉单胞菌的丰度较高。相比之下，健康对照者在多数研究中显示出较高丰度的变形菌门和放线菌门；在属水平上，链球菌属、放线菌属、棒状杆菌属、罗氏菌属和韦荣球菌属的丰度较高；在种水平上，流感嗜血杆菌、粘液罗氏菌和缓症链球菌的丰度较高。 结论：研究结果表明HNSCC患者口腔微生物群的多样性和组成存在显著改变，突显了微生物失调在癌症进展中的作用。建立标准化的口腔样本采集和微生物群分析方案，对于推动更具稳健性、可比性和临床意义的研究成果至关重要。
肿瘤(癌症)患者之家