Background/Objectives: Colorectal cancer (CRC) frequently metastasizes to the peritoneum, significantly worsening patient prognosis. While serum tumor markers such as carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) are routinely measured, their diagnostic or prognostic role in peritoneal fluid remains unclear. This study aimed to assess the relationship between CEA and CA 19-9 levels in both serum and peritoneal fluid, and the clinical stage of CRC, particularly focusing on the presence of peritoneal metastases and positive cytology. Methods: We retrospectively analyzed data from 89 patients with histologically confirmed CRC who underwent surgery between 2020 and 2023. All patients had preoperative assessment of CEA and CA 19-9 levels in serum and peritoneal fluid, along with cytological examination of peritoneal fluid samples. Patients were categorized based on the presence or absence of macroscopic peritoneal metastases and cytology results. Results: Elevated levels of CEA and CA 19-9 in peritoneal fluid were significantly associated with the presence of peritoneal metastases. A positive cytological finding also correlated with higher marker concentrations. Conclusions: CEA and CA 19-9 levels in peritoneal fluid strongly correlate with peritoneal dissemination in CRC. These markers may serve as additional predictive factors, aiding in early detection of peritoneal spread and improved risk stratification. Their assessment may be useful in guiding intraoperative and postoperative decision-making.
背景/目的：结直肠癌常发生腹膜转移，显著恶化患者预后。虽然临床常规检测血清肿瘤标志物如癌胚抗原和糖类抗原19-9，但它们在腹腔积液中的诊断或预后价值尚不明确。本研究旨在评估血清与腹腔积液中CEA和CA19-9水平与结直肠癌临床分期的关系，重点关注腹膜转移及细胞学阳性情况。方法：我们回顾性分析了2020年至2023年间接受手术治疗的89例经组织学确诊的结直肠癌患者资料。所有患者术前均接受血清及腹腔积液CEA、CA19-9检测，并行腹腔积液细胞学检查。根据肉眼可见腹膜转移及细胞学结果对患者进行分组。结果：腹腔积液中CEA和CA19-9水平升高与腹膜转移存在显著相关性。细胞学阳性结果也与更高的标志物浓度相关。结论：腹腔积液中CEA和CA19-9水平与结直肠癌腹膜播散密切相关。这些标志物可作为辅助预测因子，有助于早期发现腹膜播散并改善风险分层，其评估结果对指导术中及术后决策具有潜在价值。
肿瘤(癌症)患者之家