文章：

γδ T细胞在多形性胶质母细胞瘤中的新角色与治疗机遇

γδ T Cells in Glioblastoma Multiforme: Novel Roles and Therapeutic Opportunities

原文发布日期：15 August 2025

DOI: 10.3390/cancers17162660

类型: Article

开放获取: 是

英文摘要：

Glioblastoma multiforme (GBM) is one of the most aggressive cancers, with limited treatment options due to its highly immunosuppressive microenvironment and resistance to conventional therapies. γδ T cells, known for their potent antitumor activity and ability to recognize tumor antigens independently of HLA molecules, have emerged as a promising therapeutic strategy. This review explores the role of γδ T cells in glioblastoma, focusing on their functional plasticity, cytotoxic mechanisms, and interactions with components of the tumor microenvironment. We examine the factors that influence γδ T cell polarization toward pro- or anti-tumor phenotypes and analyze preclinical findings that support their application in GBM treatment. Furthermore, we discuss potential combinatory approaches—including immune checkpoint inhibitors, cytokine stimulation, and adoptive cell transfer techniques—to enhance the therapeutic effectiveness and persistence of γδ T cells. Understanding the dynamics between GBM and γδ T cells may pave the way for innovative immunotherapeutic strategies aimed at overcoming immune evasion and improving clinical outcomes.

摘要翻译： 

多形性胶质母细胞瘤（GBM）是最具侵袭性的恶性肿瘤之一，因其高度免疫抑制的微环境及对常规治疗的耐药性，目前治疗手段有限。γδ T细胞以其强大的抗肿瘤活性及不依赖HLA分子识别肿瘤抗原的能力，成为一种极具前景的治疗策略。本文综述了γδ T细胞在胶质母细胞瘤中的作用，重点关注其功能可塑性、细胞毒性机制以及与肿瘤微环境成分的相互作用。我们探讨了影响γδ T细胞向促肿瘤或抗肿瘤表型极化的因素，并分析了支持其应用于GBM治疗的临床前研究证据。此外，我们讨论了潜在的联合治疗策略——包括免疫检查点抑制剂、细胞因子刺激和过继性细胞转移技术——以增强γδ T细胞的治疗效果与持久性。深入理解GBM与γδ T细胞间的动态相互作用，可能为开发克服免疫逃逸、改善临床疗效的创新免疫治疗策略开辟新途径。

原文链接：

γδ T Cells in Glioblastoma Multiforme: Novel Roles and Therapeutic Opportunities