Introduction: SIMPLR-2 is a follow-up to the international, multicenter SIMPLR-1 study evaluating long-term oncological outcomes after open (OLP), laparoscopic (LLP), and robotic (RLP) left pancreatectomy for pancreatic ductal adenocarcinoma (PDAC).Methods: A retrospective analysis of 71 PDAC patients from three high-volume centers was performed. Surgical approaches were stratified into open, laparoscopic, and robotic. The primary endpoint was overall survival (OS); recurrence-free survival (RFS) was also assessed. Kaplan–Meier and Cox regression analyses were used, including propensity score adjustment.Results: Median OS was 11.0 months for OLP and 24.0 months for minimally invasive approaches (p= 0.169). Median RFS was 6 vs. 15 months, respectively (p= 0.258). No significant differences were found between surgical approaches.Conclusions: Although longer survival was observed in minimally invasive groups, differences were not statistically significant. Larger prospective trials are needed to clarify the long-term oncologic impact of a surgical approach in PDAC.
引言：SIMPLR-2是国际多中心SIMPLR-1研究的后续项目，旨在评估开放式（OLP）、腹腔镜（LLP）及机器人辅助（RLP）左半胰腺切除术治疗胰腺导管腺癌（PDAC）后的长期肿瘤学结局。 方法：对来自三家高手术量中心的71例PDAC患者进行回顾性分析。手术方式分为开放式、腹腔镜式及机器人辅助式。主要终点为总生存期（OS），同时评估无复发生存期（RFS）。采用Kaplan-Meier法和Cox回归分析，并纳入倾向评分调整。 结果：开放式手术组中位OS为11.0个月，微创手术组为24.0个月（p=0.169）；中位RFS分别为6个月与15个月（p=0.258）。不同手术方式间未发现显著差异。 结论：尽管微创手术组观察到更长的生存期，但差异无统计学意义。需要更大规模的前瞻性试验以明确手术方式对PDAC长期肿瘤学结局的影响。
肿瘤(癌症)患者之家