Background/Objectives:Melanoma is an aggressive skin cancer with increasing incidence worldwide. Dermoscopy has revolutionized early melanoma detection, but most studies have focused on the general adult population. This study aims to analyze dermoscopic and histological differences in melanoma across age groups, evaluating whether specific patterns vary between younger and older patients.Methods:This retrospective study included 285 histopathological confirmed melanomas diagnosed at the Dermatology Clinic of the University of Turin between November 2021 and April 2024. Patients were stratified by age (<40 vs. ≥40 years), and statistical analyses (Chi-square, logistic regression) assessed differences in dermoscopic, histopathological, and anatomical parameters.Results: Younger patients showed a higher prevalence of growth-related features (e.g., pseudopods, OR = 5.43; asymmetric globules, OR = 2.33) and a thicker Breslow index (mean = 1.05 mm). Older patients exhibited more regression-associated signs (scar-like depigmentation, OR = 0.15; peppering, OR = 0.39), greater lesion size, and solar elastosis. Dermoscopic regression significantly predicted histological regression, with age-stratified analysis revealing peppering as a predictor in younger patients (p= 0.015) and scar-like depigmentation in older ones (p= 0.012).Conclusions: Melanoma exhibits distinct dermoscopic features depending on patient age, with growth-associated patterns being more common in younger individuals and regressive patterns predominating in older patients. These findings highlight the importance of age-specific diagnostic considerations in melanoma detection, potentially improving early diagnosis and patient outcomes.
**背景/目的：** 黑色素瘤是一种侵袭性皮肤癌，全球发病率不断上升。皮肤镜检查革新了黑色素瘤的早期检测，但大多数研究聚焦于一般成年人群。本研究旨在分析不同年龄组黑色素瘤的皮肤镜及组织学差异，评估特定模式在年轻与年长患者之间是否存在差异。 **方法：** 这项回顾性研究纳入了2021年11月至2024年4月期间在都灵大学皮肤病诊所确诊的285例经组织病理学证实的黑色素瘤。患者按年龄分层（<40岁 vs. ≥40岁），并通过统计分析（卡方检验、逻辑回归）评估了皮肤镜、组织病理学和解剖学参数的差异。 **结果：** 年轻患者表现出更高的生长相关特征发生率（例如，伪足，OR = 5.43；不对称球状结构，OR = 2.33）和更厚的Breslow指数（平均值 = 1.05 mm）。年长患者则表现出更多与退行相关的征象（瘢痕样色素脱失，OR = 0.15；胡椒样颗粒，OR = 0.39）、更大的皮损面积以及日光性弹力纤维变性。皮肤镜下的退行征象能显著预测组织学上的退行，年龄分层分析显示，胡椒样颗粒是年轻患者的预测因子（p=0.015），而瘢痕样色素脱失是年长患者的预测因子（p=0.012）。 **结论：** 黑色素瘤的皮肤镜特征因患者年龄而异，生长相关模式在年轻个体中更常见，而退行模式在年长患者中占主导。这些发现强调了在黑色素瘤检测中考虑年龄特异性诊断因素的重要性，可能有助于改善早期诊断和患者预后。
Dermoscopy of Melanoma According to Age Groups: A Retrospective Monocentric Study on 285 Patients
肿瘤(癌症)患者之家