文章：

利用化学交换饱和转移与扩散加权成像评估X射线疗法对胶质瘤大鼠模型的影响

Evaluation of the Effect of X-Ray Therapy on Glioma Rat Model Using Chemical Exchange Saturation Transfer and Diffusion-Weighted Imaging

原文发布日期：5 August 2025

DOI: 10.3390/cancers17152578

类型: Article

开放获取: 是

英文摘要：

Background/Objectives: This study aimed to examine the changes in brain metabolites and water molecule diffusion using chemical exchange saturation transfer (CEST) imaging and diffusion-weighted imaging (DWI) after 15 Gy of X-ray irradiation in a rat model of glioma.Methods: The glioma-derived cell line, C6, was implanted into the striatum of the right brain of 7-week-old male Wistar rats. CEST imaging and DWI were performed on days 8, 10, and 17 after implantation using a 7T-magnetic resonance imaging. X-ray irradiation (15 Gy) was performed on day 9. Magnetization transfer ratio (MTR) and apparent diffusion coefficient (ADC) values were calculated for CEST and DWI, respectively.Results: On day 17, the MTR values at 1.2 ppm, 1.5 ppm, 1.8 ppm, 2.1 ppm, and 2.4 ppm in the irradiated group decreased significantly compared with those of the control group. The standard deviation for the ADC values on a pixel-by-pixel basis increased from day 8 to day 17 (0.6 ± 0.06 → 0.8 ± 0.17 (×10−3mm2/s)) in the control group, whereas it remained nearly unchanged (0.6 ± 0.06 → 0.8 ± 0.11 (×10−3mm2/s)) in the irradiated group.Conclusions: This study revealed the effects of 15 Gy X-ray irradiation in a rat model of glioma using CEST imaging and DWI.

摘要翻译： 

背景/目的：本研究旨在通过化学交换饱和转移（CEST）成像与扩散加权成像（DWI），探究大鼠胶质瘤模型在接受15 Gy X射线照射后脑代谢物及水分子扩散的变化。 方法：将胶质瘤来源的C6细胞系植入7周龄雄性Wistar大鼠右侧脑纹状体。在植入后第8、10、17天使用7T磁共振成像系统进行CEST成像与DWI扫描。X射线照射（15 Gy）于第9天实施。分别计算CEST的磁化转移率（MTR）及DWI的表观扩散系数（ADC）值。 结果：照射组在第17天时，1.2 ppm、1.5 ppm、1.8 ppm、2.1 ppm及2.4 ppm处的MTR值较对照组显著下降。对照组ADC值的像素间标准差从第8天至第17天逐渐增加（0.6 ± 0.06 → 0.8 ± 0.17 (×10−3mm²/s)），而照射组则基本保持不变（0.6 ± 0.06 → 0.8 ± 0.11 (×10−3mm²/s)）。 结论：本研究通过CEST成像与DWI技术揭示了15 Gy X射线照射对大鼠胶质瘤模型的影响。

原文链接：

Evaluation of the Effect of X-Ray Therapy on Glioma Rat Model Using Chemical Exchange Saturation Transfer and Diffusion-Weighted Imaging