文章：

构建骨髓微环境模型以深入理解血液系统癌症的发病机制、进展及治疗策略

Modeling the Bone Marrow Microenvironment to Better Understand the Pathogenesis, Progression, and Treatment of Hematological Cancers

原文发布日期：4 August 2025

DOI: 10.3390/cancers17152571

类型: Article

开放获取: 是

英文摘要：

Despite significant advancements in understanding the pathogenesis and treatment of hematological malignancies, including leukemia and multiple myeloma, the majority of patients continue to experience poor long-term outcomes. This is partly due to the difficulty of accurately recapitulating the malignant microenvironment in vitro, particularly the bone marrow niche. The complexity of the bone marrow microenvironment poses a challenge for the in vitro examination of hematological malignancies. Traditionally, 2D culture and animal models have been utilized, but these representations are limited and have been criticized for their lack of human physiological relevance. In an attempt to overcome this, 3D models have been developed that more accurately recapitulate the in vivo microenvironment. Herein, we present an overview of recent developments in 2D and 3D models used for studying the bone marrow niche in hematological malignancies, highlighting their advantages and limitations.

摘要翻译： 

尽管在理解白血病和多发性骨髓瘤等血液恶性肿瘤的发病机制及治疗方面取得了显著进展，但大多数患者的长期预后仍然不佳。这部分归因于在体外准确模拟恶性微环境，尤其是骨髓微环境的困难。骨髓微环境的复杂性给血液恶性肿瘤的体外研究带来了挑战。传统上，二维培养和动物模型被广泛使用，但这些模型存在局限性，并因缺乏人类生理相关性而受到批评。为了克服这一问题，三维模型应运而生，能够更准确地模拟体内微环境。本文综述了用于研究血液恶性肿瘤中骨髓微环境的二维和三维模型的最新进展，并重点讨论了它们的优势和局限性。

原文链接：

Modeling the Bone Marrow Microenvironment to Better Understand the Pathogenesis, Progression, and Treatment of Hematological Cancers