Background: Chemotherapy-induced peripheral neuropathy is a common and debilitating side effect of cancer treatment. While exercise has shown promise in alleviating this burden, it remains underutilised in clinical practice due to the lack of accessible, clinician-friendly guidance. Aim: This review aimed to synthesise current evidence on exercise interventions for managing chemotherapy-induced peripheral neuropathy and provide practical insights to support clinicians in integrating these approaches into patient care. Methods: A search was conducted across MEDLINE, CINAHL, and SPORTDiscus using keywords related to exercise and CIPN. Studies were included if they involved adults receiving neurotoxic chemotherapy and exercise-based interventions. Two authors independently screened studies and resolved conflicts with a third author. Study quality was assessed using the JBI Critical Appraisal Tools, and only studies meeting a minimum quality standard were included. A balanced sampling approach was employed. Data on study design, participant characteristics, interventions, and outcomes were extracted. Results: Eleven studies were included, covering various exercise modalities: multimodal (n = 5), yoga (n = 2), aerobic (n = 1), resistance (n = 1), balance (n = 1), and sensorimotor (n = 1). Exercise interventions, particularly multimodal exercise, significantly improved symptom severity, functionality, and quality of life (p< 0.05). The studies had high methodological quality, with randomised controlled trials scoring between 9/13 and 11/13, and quasi-experimental studies scoring 8/9 on JBI tools. Conclusions: This review highlights the significant benefits of exercise, especially multimodal exercise, for managing CIPN and provides guidance for integrating these strategies into clinical practice. Future research is needed to refine exercise prescriptions and develop standardised guidelines.
背景：化疗所致周围神经病变是癌症治疗中常见且具有致残性的副作用。尽管运动疗法在缓解这一负担方面显示出潜力，但由于缺乏易于获取且便于临床医生操作的指导，其在临床实践中仍未得到充分利用。目的：本综述旨在综合当前关于运动干预管理化疗所致周围神经病变的证据，并提供实用见解以支持临床医生将这些方法整合到患者护理中。方法：通过MEDLINE、CINAHL和SPORTDiscus数据库，使用与运动和CIPN相关的关键词进行检索。纳入标准为涉及接受神经毒性化疗的成人患者及基于运动干预的研究。由两位作者独立筛选文献，分歧由第三位作者协助解决。研究质量采用JBI批判性评估工具进行评价，仅纳入符合最低质量标准的研究。采用平衡抽样策略，提取研究设计、参与者特征、干预措施及结局指标等数据。结果：共纳入11项研究，涵盖多种运动形式：多模式运动（5项）、瑜伽（2项）、有氧运动（1项）、抗阻运动（1项）、平衡训练（1项）和感觉运动训练（1项）。运动干预，尤其是多模式运动，显著改善了症状严重程度、功能状态和生活质量（p<0.05）。研究方法学质量较高，随机对照试验在JBI工具中得分介于9/13至11/13之间，类实验研究得分为8/9。结论：本综述强调了运动（特别是多模式运动）对管理CIPN的显著益处，并为将这些策略整合到临床实践提供了指导。未来研究需进一步完善运动处方并制定标准化指南。
肿瘤(癌症)患者之家