Colorectal liver metastasis (CRLM) poses a significant challenge in oncology due to its high incidence and poor prognosis in unresectable cases. Current treatments, including surgical resection, systemic chemotherapy, and liver-directed therapies, often fail to effectively target hypoxic tumor regions, which are inherently more resistant to these interventions. This review examines the potential of a novel therapeutic strategy combining irreversible electroporation (IRE) ablation andClostridium novyi-nontoxic (C.novyi-NT) bacterial therapy. IRE is a non-thermal tumor ablation technique that uses high-voltage electric pulses to create permanent nanopores in cell membranes, leading to cell death while preserving surrounding structures, and is often associated with temporary tumor hypoxia due to disrupted perfusion.C.novyi-NT is an attenuated, anaerobic bacterium engineered to selectively germinate and proliferate in hypoxic tumor regions, resulting in localized tumor cell lysis while sparing healthy, oxygenated tissue. The synergy between IRE-induced hypoxia and hypoxia-sensitiveC.novyi-NT may enhance tumor destruction and stimulate systemic antitumor immunity. Furthermore, the integration of advanced imaging and artificial intelligence can support precise treatment planning and real-time monitoring. This integrated approach holds promise for improving outcomes in patients with CRLM, though further preclinical and clinical validation is needed.
结直肠癌肝转移（CRLM）因其高发病率及不可切除病例预后不良，成为肿瘤学领域的重大挑战。当前治疗手段包括手术切除、全身化疗和肝脏定向疗法，但常难以有效靶向缺氧肿瘤区域，这些区域对这些干预措施具有天然抵抗性。本文综述了一种结合不可逆电穿孔（IRE）消融与无毒诺维梭菌（C.novyi-NT）细菌治疗的新型策略潜力。IRE是一种非热肿瘤消融技术，通过高压电脉冲在细胞膜上形成永久性纳米孔导致细胞死亡，同时保护周围组织结构，并常因灌注中断引发暂时性肿瘤缺氧。C.novyi-NT是一种经过基因改造的减毒厌氧菌，能选择性地在缺氧肿瘤区域萌发增殖，导致局部肿瘤细胞裂解而不损伤健康富氧组织。IRE诱导的缺氧与缺氧敏感的C.novyi-NT之间的协同作用，可能增强肿瘤破坏效果并激发全身抗肿瘤免疫。此外，结合先进成像与人工智能技术可支持精准治疗规划和实时监测。这一整合疗法虽需进一步临床前及临床验证，但有望改善CRLM患者的治疗结局。
肿瘤(癌症)患者之家