Background/Objectives: Endometrial cancer (EC) is the most prevalent gynecological malignancy, with increasing incidence and mortality. HOXA5, a developmental transcription factor, has been linked to prognosis in various cancers, but its role in EC remains unclear. This study aimed to evaluate the prognostic potential of HOXA5 in EC and to explore its association with common tumor-related proteins.Methods: We analyzed 75 EC tissue samples using immunohistochemistry to evaluate HOXA5 expression and its association with clinicopathological features and tumor-related biomarkers, including Ki-67, CD31, and fibronectin. Statistical analyses included logistic regression and Kaplan–Meier survival analysis.Results: High HOXA5 expression was significantly associated with elevated Ki-67 levels (p= 0.001) but paradoxically correlated with improved overall survival (p= 0.026). CD31 and fibronectin levels were significantly lower in the high-HOXA5 group (p= 0.007 andp= 0.001, respectively), suggesting reduced angiogenic and invasive potential. However, neither marker remained significant in multivariable analysis.Conclusions: HOXA5 may exert a dual role in EC by promoting proliferation while limiting tumor progression via suppression of angiogenesis and matrix remodeling. It holds potential as a prognostic biomarker and therapeutic target.
背景/目的：子宫内膜癌是最常见的妇科恶性肿瘤，其发病率和死亡率呈上升趋势。HOXA5作为一种发育转录因子，已在多种癌症中被证实与预后相关，但其在子宫内膜癌中的作用尚不明确。本研究旨在评估HOXA5在子宫内膜癌中的预后价值，并探讨其与常见肿瘤相关蛋白的关联。方法：我们通过免疫组织化学方法分析75例子宫内膜癌组织样本，评估HOXA5表达及其与临床病理特征、肿瘤相关生物标志物（包括Ki-67、CD31和纤连蛋白）的关联。统计分析采用逻辑回归和Kaplan-Meier生存分析。结果：HOXA5高表达与Ki-67水平升高显著相关（p=0.001），但矛盾的是，其与改善的总生存期相关（p=0.026）。高HOXA5组中CD31和纤连蛋白水平显著降低（分别为p=0.007和p=0.001），提示血管生成和侵袭潜能减弱。然而，在多变量分析中这两个标志物均未保持显著性。结论：HOXA5可能通过促进细胞增殖，同时抑制血管生成和基质重塑来限制肿瘤进展，从而在子宫内膜癌中发挥双重作用。它有望成为预后生物标志物和治疗靶点。
HOXA5 as a Dual Modulator of Tumor Biology in Endometrial Cancer
肿瘤(癌症)患者之家