文章：

靶向Wnt信号通路治疗急性淋巴细胞白血病

Targeting Wnt Signaling in Acute Lymphoblastic Leukemia

原文发布日期：24 July 2025

DOI: 10.3390/cancers17152456

类型: Article

开放获取: 是

英文摘要：

The Wnt signaling pathway plays a critical role in regulating normal hematopoiesis and immune cell development. However, its dysregulation has emerged as a key driver of leukemogenesis. Leukemic stem cells exploit aberrant Wnt signaling to sustain self-renewal, evade apoptosis, and promote unchecked proliferation. In this review, we highlight the dual roles of canonical and non-canonical Wnt pathways in acute leukemia, emphasizing their distinct and overlapping contributions to disease progression. We also evaluate current preclinical and clinical strategies targeting Wnt signaling, identifying both promising advances and persistent obstacles to therapeutic translation. By elucidating the molecular mechanisms underlying Wnt pathway dysregulation in leukemic cells, this review underscores the potential of Wnt-directed therapies as a novel class of interventions to improve outcomes for patients with acute leukemia.

摘要翻译： 

Wnt信号通路在调控正常造血及免疫细胞发育过程中发挥关键作用，但其功能失调已成为白血病发生的重要驱动因素。白血病干细胞通过异常激活Wnt信号通路维持自我更新能力、逃避细胞凋亡并促进失控性增殖。本综述系统阐述经典与非经典Wnt通路在急性白血病中的双重作用，重点解析二者在疾病进展过程中既相互独立又彼此协同的调控机制。同时评估当前靶向Wnt信号通路的临床前及临床研究策略，明确该领域取得的突破性进展与治疗转化面临的主要挑战。通过阐明白血病细胞中Wnt通路失调的分子机制，本文强调靶向Wnt通路治疗策略作为新型干预手段在改善急性白血病患者预后方面的潜在价值。

原文链接：

Targeting Wnt Signaling in Acute Lymphoblastic Leukemia