文章：

EGFR突变非小细胞肺癌脑实质与软脑膜转移的临床图景及治疗策略

The Landscape and Management of Brain Parenchymal and Leptomeningeal Metastases in EGFR Mutated Non-Small Cell Lung Cancer

原文发布日期：23 July 2025

DOI: 10.3390/cancers17152434

类型: Article

开放获取: 是

英文摘要：

Central nervous system metastases involving the brain parenchyma and leptomeninges are common in non-small cell lung cancer, especially cases withEGFRmutations. Here, we examine treatment options forEGFR-mutated non-small cell lung cancer patients with central nervous system metastases, highlighting the efficacy of third-generationEGFR-targeted tyrosine kinase inhibitors. Furthermore, we examine the interplay of this modality with chemotherapy or radiation in resistant cases.

摘要翻译： 

中枢神经系统转移，包括脑实质和软脑膜转移，在非小细胞肺癌中较为常见，尤其是在携带EGFR突变的病例中。本文探讨了针对伴有中枢神经系统转移的EGFR突变非小细胞肺癌患者的治疗方案，重点分析了第三代EGFR靶向酪氨酸激酶抑制剂的疗效。此外，我们还研究了在耐药病例中，该治疗方式与化疗或放疗的相互作用。

原文链接：

The Landscape and Management of Brain Parenchymal and Leptomeningeal Metastases in EGFR Mutated Non-Small Cell Lung Cancer