Background/Objectives: This study evaluates the effects of a personalized exercise program on symptoms (pain, fatigue, sleep, cognitive function, physical function), resilience, and health-related quality of life (HRQOL) and compares the effectiveness of in-person versus telehealth delivery.Methods: A secondary data analysis was conducted on two 12-week randomized control pilot studies for solid tumor cancer survivors. One study involved in-person home visits with telephone follow-ups. The second utilized weekly exercise recommendations via a smartphone app. Both studies had control participants who received the standard care. Symptoms, resilience, and HRQOL were measured at baseline and after 12 weeks. Paired t-tests were conducted for intervention effects and ANCOVA for group differences, adjusting for age and education.Results: The analysis included 75 program completers: 15 in-person (iHBE), 38 telehealth (TEHE), and 22 who received standard care. Those receiving exercise interventions reported improvements in physical (t = 3.0,p< 0.01) and mental fatigability (t = 3.1,p< 0.01) at program completion compared to baseline. Comparing the mean changes between participants receiving exercise interventions in-person and via telehealth, there were no significant differences between the two delivery methods except perceived visuo-perceptual cognitive difficulty (F = 3.55,p= 0.027), where telehealth showed a slight advantage.Conclusions: The study provides initial evidence of the effectiveness of a telehealth personalized exercise on fatigability and cognitive difficulty, suggesting it is a potential viable alternative to in-person intervention. Further research with a larger cohort is essential to ascertain the effects of these interventional modalities on cancer-related health outcomes.
**背景/目的：** 本研究评估了个性化运动方案对症状（疼痛、疲劳、睡眠、认知功能、身体功能）、心理弹性及健康相关生活质量的影响，并比较了面对面与远程医疗两种实施方式的效果。 **方法：** 本研究对两项针对实体瘤癌症幸存者的为期12周的随机对照预试验进行了二次数据分析。其中一项研究采用家庭访视结合电话随访的方式。第二项研究则通过智能手机应用程序提供每周运动建议。两项研究均设有接受标准护理的对照组。在基线期和12周后分别测量了症状、心理弹性和健康相关生活质量。采用配对t检验分析干预效果，并采用协方差分析比较组间差异，同时校正了年龄和教育水平。 **结果：** 分析共纳入75名完成项目的参与者：15名接受面对面干预，38名接受远程医疗干预，22名接受标准护理。与基线相比，接受运动干预的参与者在项目完成时报告了身体疲劳性（t = 3.0, p < 0.01）和精神疲劳性（t = 3.1, p < 0.01）的改善。比较面对面与远程医疗两种方式下接受运动干预参与者的平均变化，除感知视觉-知觉认知困难（F = 3.55, p = 0.027）外，两种实施方式之间无显著差异，其中远程医疗方式显示出轻微优势。 **结论：** 本研究提供了初步证据，表明远程医疗个性化运动方案对改善疲劳性和认知困难有效，提示其可能是面对面干预的一种潜在可行的替代方案。未来需要更大样本量的研究，以确定这些干预模式对癌症相关健康结局的影响。
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