Despite being a rare malignancy, there have been several changes in the management paradigm for vulvar cancer. This review of the literature was undertaken to highlight key areas of treatment innovation and progress, including efforts to de-escalate morbid surgical resection as well as perform dose escalation of radiotherapy and incorporation of modern systemic agents to achieve better oncologic outcomes. There is still much debate regarding key high-risk pathology features and their corresponding prognostic significance and indications for adjuvant treatments. However, we are also developing a more nuanced understanding of the importance of precursor lesions and resultant subtypes of vulvar cancer, which suggests that there are more subtypes beyond the umbrella distinction of HPV status. Moving forward, we anticipate there will be an increasing number of trials investigating the triaging of management recommendations based on risk.
尽管外阴癌是一种罕见恶性肿瘤，其治疗模式已发生多项变革。本文通过文献综述，重点阐述治疗创新与进展的关键领域，包括减少致残性手术切除的尝试、提高放疗剂量以及联合应用现代全身性药物以改善肿瘤学预后。目前针对高危病理特征及其对应的预后意义与辅助治疗指征仍存在诸多争议。然而，我们对癌前病变重要性及其导致的外阴癌亚型有了更深入的理解，这表明除HPV状态这一总体区分外，还存在更多亚型分类。展望未来，我们预计将有更多临床试验探索基于风险分层的治疗建议分级策略。
肿瘤(癌症)患者之家