文章：

食管鳞状乳头状瘤与乳头状瘤病：当前HPV参与及恶性潜能的证据

Esophageal Squamous Papilloma and Papillomatosis: Current Evidence of HPV Involvement and Malignant Potential

原文发布日期：20 July 2025

DOI: 10.3390/cancers17142404

类型: Article

开放获取: 是

英文摘要：

Human papillomavirus (HPV) is a recognized oncogenic agent in several epithelial malignancies, though its role in esophageal squamous lesions remains unclear. Esophageal squamous papilloma and papillomatosis are rare, often benign lesions, but increasing evidence suggests possible associations with high-risk HPV genotypes and a non-negligible risk of dysplasia and malignant transformation. This narrative review summarizes current evidence on epidemiology, clinical features, histopathology, and diagnostic approaches, emphasizing advanced endoscopic imaging techniques that improve lesion detection and characterization. Management relies primarily on complete endoscopic resection with histological and virological evaluation. While small, non-dysplastic solitary lesions may not require routine surveillance, multifocal or high-risk HPV-positive cases warrant closer follow-up. Standardized HPV testing and long-term prospective studies are needed to better define the oncogenic potential and inform surveillance and treatment strategies.

摘要翻译： 

人乳头瘤病毒（HPV）是多种上皮性恶性肿瘤的公认致癌因子，但其在食管鳞状上皮病变中的作用尚不明确。食管鳞状乳头状瘤及乳头状瘤病较为罕见，通常为良性病变，但越来越多的证据表明其可能与高危型HPV感染相关，且存在不可忽视的上皮内瘤变及恶变风险。本文综述了当前关于该病流行病学、临床特征、组织病理学及诊断方法的研究证据，重点探讨了能够提升病变检出与特征识别能力的内镜成像新技术。临床治疗主要依赖于内镜下完整切除并进行组织学与病毒学评估。对于体积较小、无非典型增生的孤立性病变可能无需常规监测，而多灶性病变或高危型HPV阳性病例则需加强随访。未来需通过标准化HPV检测及长期前瞻性研究，以更准确地评估其致癌潜力，并为临床监测与治疗策略的制定提供依据。

原文链接：

Esophageal Squamous Papilloma and Papillomatosis: Current Evidence of HPV Involvement and Malignant Potential