文章：

三结构域蛋白在泌尿系统癌症中的作用：一项系统性综述

The Roles of Tripartite Motif Proteins in Urological Cancers: A Systematic Review

原文发布日期：16 July 2025

DOI: 10.3390/cancers17142367

类型: Article

开放获取: 是

英文摘要：

We aimed to investigate the roles of tripartite motif (TRIM) proteins in urological cancers.Methods: A systematic review was conducted to investigate the oncological role of tripartite motif proteins in urological cancers.Results: A total of 84 articles were identified for the final analysis (26 articles on kidney cancers, 19 on bladder cancers, 37 on prostate cancers, and 1 on testicular cancers). In total, 27 TRIM family proteins were involved in kidney cancer, of which 9 were associated with tumor-promoting findings (TRIM24, TRIM27, TRIM37, TRIM44, TRIM46, TRIM47, TRIM59, TRIM63, and TRIM65) and of which 9 TRIM proteins were tumor-suppressive (TRIM2, TRIM7, TRIM8, TRIM13, TRIM21, TRIM26, TRIM28, TRIM33, and TRIM58). Fourteen TRIM family proteins were associated with bladder cancer (tumor-promoting: TRIM9, TRIM25, TRIM26, TRIM28, TRIM29, TRIM59, TRIM65, and TRIM66; tumor-suppressive: TRIM19 and TRIM38). Ten TRIM family proteins were associated with prostate cancer (tumor-promoting: TRIM11, TRIM24, TRIM28, TRIM33, TRIM44, TRIM59, TRIM63, TRIM66, and TRIM68; tumor-suppressive: TRIM32 and TRIM36). Twenty-eight TRIM family proteins were identified to be associated with prostate cancer (tumor-promoting: TRIM11, TRIM24, TRIM28, TRIM33, TRIM44, TRIM59, TRIM63, TRIM66, and TRIM68; tumor-suppressive: TRIM32 and TRIM36). TRIM proteins regulate urological cancers by ubiquitination or modulation of oncologic pathways.Conclusions: This review identifies TRIM proteins that are involved in urological cancers. Some of these proteins have the potential to be the therapeutic target.

摘要翻译： 

本研究旨在探讨三结构域（TRIM）蛋白在泌尿系统肿瘤中的作用。方法：通过系统综述方法，系统分析三结构域蛋白在泌尿系统肿瘤中的肿瘤学作用。结果：共纳入84篇文献进行最终分析（肾癌26篇、膀胱癌19篇、前列腺癌37篇、睾丸癌1篇）。研究发现27种TRIM家族蛋白与肾癌相关，其中9种具有促癌作用（TRIM24、TRIM27、TRIM37、TRIM44、TRIM46、TRIM47、TRIM59、TRIM63和TRIM65），9种具有抑癌作用（TRIM2、TRIM7、TRIM8、TRIM13、TRIM21、TRIM26、TRIM28、TRIM33和TRIM58）。14种TRIM家族蛋白与膀胱癌相关（促癌蛋白：TRIM9、TRIM25、TRIM26、TRIM28、TRIM29、TRIM59、TRIM65和TRIM66；抑癌蛋白：TRIM19和TRIM38）。10种TRIM家族蛋白与前列腺癌相关（促癌蛋白：TRIM11、TRIM24、TRIM28、TRIM33、TRIM44、TRIM59、TRIM63、TRIM66和TRIM68；抑癌蛋白：TRIM32和TRIM36）。TRIM蛋白主要通过泛素化修饰或调控肿瘤信号通路参与泌尿系统肿瘤的调控。结论：本综述系统鉴定了参与泌尿系统肿瘤发生发展的TRIM蛋白，其中部分蛋白具有成为治疗靶点的潜力。

原文链接：

The Roles of Tripartite Motif Proteins in Urological Cancers: A Systematic Review