Ovarian cancer remains one of the most lethal gynecological malignancies, primarily due to its late diagnosis and limited prospects for successful treatment. MiRNAs have been shown to be important post-transcriptional regulators in a variety of cancer-related pathways in recent years. One of the principal mechanisms underlying the motility, invasiveness, and metastatic potential of ovarian cancer cells is the microRNA-mediated regulation of ABPs. As integral components of the cytoskeletal network, ABPs participate in dynamic cellular processes such as migration, adhesion, and invasion, and are critically involved in tumor development and progression. Recent data indicate that some miRNAs affect ABP expression and activity, which in turn affects cytoskeletal remodeling and, ultimately, tumor cell behavior. The role of miRNAs in cancer development is inherently complex due to their ability to function as both tumor suppressors and oncogenes, depending on the molecular context. Key ABPs that are targeted by particular miRNAs are discussed in terms of their clinical relevance, including their potential utility as diagnostic biomarkers or therapeutic targets. A deeper understanding of these regulatory pathways may offer new opportunities for early detection and personalized treatment strategies. In this narrative review, the current knowledge of how miRNAs affect ABP expression and function, and how this interaction contributes to the development and progression of ovarian cancer, is compiled.
卵巢癌因其诊断延迟和治疗前景有限，仍是致死率最高的妇科恶性肿瘤之一。近年来研究表明，微小RNA（miRNA）在多种癌症相关通路中发挥重要的转录后调控作用。卵巢癌细胞运动、侵袭及转移潜能的核心机制之一，正是通过miRNA介导的肌动蛋白结合蛋白（ABP）调控实现的。作为细胞骨架网络的关键组分，ABP参与细胞迁移、黏附和侵袭等动态过程，在肿瘤发生发展中起决定性作用。最新证据显示，特定miRNA通过调控ABP的表达与活性，影响细胞骨架重塑，最终改变肿瘤细胞行为。miRNA在癌症发展中的作用具有内在复杂性——其既可充当抑癌因子也可作为癌基因，具体功能取决于分子微环境。本文系统综述了特定miRNA靶向关键ABP的临床意义，包括其作为诊断生物标志物或治疗靶点的潜在价值。深入解析这些调控通路或将为早期检测和个体化治疗提供新思路。本叙述性综述整合了当前关于miRNA如何调控ABP表达与功能，以及该相互作用如何影响卵巢癌发生发展的最新认知。
肿瘤(癌症)患者之家