Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy. CIPN can lead to a dose reduction and/or the interruption of chemotherapy, limiting its effectiveness, while chronic CIPN decreases patients’ quality of life. Improvements in cancer treatment and patients’ survival have increased the number of patients living with CIPN. The only evidence-based treatment for CIPN-related pain, duloxetine, provides only modest clinical benefit, and there is no effective clinical management option for numbness and tingling. Several experimental studies and clinical reports suggest that adjuvant ozone treatment may be beneficial in managing CIPN. Methods: This narrative review aims to provide an overview of current knowledge regarding CIPN and ozone therapy. Specifically, it summarizes experimental studies (18) and clinical reports (27) published between 1995 and 2025 that offer preliminary evidence supporting the potential role of ozone treatment in managing CIPN, highlighting the need for ongoing randomized clinical trials to establish its efficacy. Additionally, this review highlights existing gaps in the literature and proposes directions for future research. Results: The hypothesized mechanisms of action and experimental findings suggest that ozone therapy may be a valuable intervention for CIPN, a concept supported by preliminary clinical observations. Conclusions: Clinically relevant approaches for established CIPN are currently unavailable. While preliminary data suggest a potential role of ozone therapy, clinical evidence remains limited. Further high-quality randomized controlled trials are needed to confirm its efficacy and safety in this context; several trials are currently ongoing.
背景：化疗诱导的周围神经病变（CIPN）是化疗常见的副作用。CIPN可能导致化疗剂量减少和/或中断，从而限制其疗效，而慢性CIPN则会降低患者的生活质量。随着癌症治疗的进步和患者生存期的延长，罹患CIPN的患者数量日益增加。目前唯一基于证据的CIPN相关疼痛治疗药物度洛西汀仅能提供有限的临床获益，且针对麻木和刺痛症状尚无有效的临床管理方案。多项实验研究和临床报告提示，辅助性臭氧治疗可能对管理CIPN具有积极作用。 方法：本叙述性综述旨在概述当前关于CIPN与臭氧治疗的认知。具体而言，本文汇总了1995年至2025年间发表的实验研究（18项）和临床报告（27项），这些研究为臭氧治疗在CIPN管理中的潜在作用提供了初步证据，并强调了开展持续随机临床试验以验证其疗效的必要性。此外，本综述还指出了现有文献中的空白领域，并为未来研究方向提出建议。 结果：基于作用机制的假设和实验研究发现，臭氧治疗可能成为CIPN的有效干预手段，这一观点已得到初步临床观察的支持。 结论：目前对于已确诊的CIPN尚缺乏具有临床意义的治疗方案。虽然初步数据显示臭氧治疗可能具有潜在价值，但临床证据仍然有限。需要进一步开展高质量随机对照试验以验证其在此背景下的疗效与安全性；目前已有若干相关试验正在进行中。
肿瘤(癌症)患者之家