文章：

高级别浆液性卵巢癌患者肿瘤浸润淋巴细胞与炎症状态对生存结局的关联性研究

Association of Tumor-Infiltrating Lymphocytes and Inflammation Status with Survival Outcome in Patients with High-Grade Serous Ovarian Carcinoma

原文发布日期：8 July 2025

DOI: 10.3390/cancers17142269

类型: Article

开放获取: 是

英文摘要：

Background/Objectives: Tumor-infiltrating lymphocytes (TILs) and inflammation status are emerging prognostic markers in various cancers, but their significance in high-grade serous ovarian carcinoma (HGSC) remains unclear. Our objective was to evaluate different TIL subtypes and inflammation status in relation to progression-free survival (PFS) in primary HGSC.Methods: CD3+/CD4+/CD8+/PD-1+ stromal TILs (sTILs) and intraepithelial TILs (iTILs) were evaluated by manual assessment and digital image analysis (DIA), following TIL Working Group recommendations. Inflammation status was evaluated through the following scores: systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), CA125, and lactate dehydrogenase (LDH).Results: CD8+TILs were the most prevalent subtype in both iTILs and sTILs. However, sTILs were significantly more abundant than iTILs (p< 0.001) among all subsets, except for PD-1+ cells. DIA results of TIL assessments were in agreement with manual assessments. High stromal CD3+and CD8+TILs, PIV, CA125, and LDH, were associated with improved PFS. Potential independent prognostic factors for PFS in manual assessment were PIV (HR = 0.32, CI 95% = 0.12–0.82) and CD8+sTILs (HR = 0.30, CI 95% = 0.12–0.79), whereas in DIA assessment they were CD3+sTILs (HR = 0.31, CI 95% = 0.15–0.67), PIV (HR = 0.35, 95% CI 0.13–0.96), and residual disease (HR = 0.21 95% CI 0.08–0.53).Conclusions: CD3+/CD8+sTILs and PIV are promising prognostic indicators in HGSC; however, further research is needed to confirm their clinical utility.

摘要翻译： 

背景/目的：肿瘤浸润淋巴细胞（TILs）与炎症状态已成为多种癌症的新型预后标志物，但其在高级别浆液性卵巢癌（HGSC）中的意义尚不明确。本研究旨在评估原发性HGSC中不同TIL亚型及炎症状态与无进展生存期（PFS）的相关性。方法：依据TIL工作组指南，通过人工评估与数字图像分析（DIA）对CD3+/CD4+/CD8+/PD-1+基质TILs（sTILs）和上皮内TILs（iTILs）进行检测。炎症状态通过以下指标评估：全身免疫炎症指数（SII）、泛免疫炎症值（PIV）、CA125及乳酸脱氢酶（LDH）。结果：CD8+TILs在iTILs与sTILs中均为最主要亚型。除PD-1+细胞外，所有亚群中sTILs数量均显著高于iTILs（p<0.001）。TILs的DIA检测结果与人工评估结果一致。高基质CD3+与CD8+TILs、高PIV、高CA125及高LDH水平与更优的PFS相关。人工评估中PIV（HR=0.32，95%CI=0.12–0.82）与CD8+sTILs（HR=0.30，95%CI=0.12–0.79）可能是PFS的独立预后因素；而DIA评估中CD3+sTILs（HR=0.31，95%CI=0.15–0.67）、PIV（HR=0.35，95%CI=0.13–0.96）及残留病灶（HR=0.21，95%CI=0.08–0.53）可能成为独立预后因素。结论：CD3+/CD8+sTILs与PIV是HGSC中具有潜力的预后指标，但其临床价值仍需进一步研究验证。

原文链接：

Association of Tumor-Infiltrating Lymphocytes and Inflammation Status with Survival Outcome in Patients with High-Grade Serous Ovarian Carcinoma