Background/Objectives: Osteopontin (OPN) is a 34 kDa protein that is extensively phosphorylated and rich in aspartic acid, produced by a single-copy gene, and altered by post-translational processes. In several diseases, OPN has been discovered to play a direct role in immunological and inflammatory responses. It is also important in kidney stone disease, preeclampsia, cardiovascular disease, endometriosis, and cancer, among other pathological conditions. It is a crucial extracellular matrix molecule involved in oncology, due to its ability to bridge the gap between inflammation and carcinogenesis. Methods: Our systematic review has as PICO “Does Osteopontin have possible etiological and prognostic correlations in patients affected by endometrial carcinoma?” Based on online data collected from PubMed, Scholar, Embase, Scopus, and other sources, a preliminary analysis was conducted. A keyword search for “Osteopontin” AND “tumors”, “endometrial cancer”, and other related terms was used to identify the publications. The relevance of scientific research was used to select articles in English. Results: For our systematic review, the citation search yielded nine articles on the topic. At the endometrial level, OPN plays a role in a variety of biological processes, including angiogenesis, metastasis, altered tissue remodeling, immunological responses, cell adhesion, and migration. Conclusions: With established direct correlations and a potential role in the assessment of the diagnosis and prognosis of the disease, OPN participates in endometrial cancer, drawing more and more attention from researchers.
背景/目的：骨桥蛋白（OPN）是一种分子量为34 kDa的蛋白质，具有广泛磷酸化特性且富含天冬氨酸，由单拷贝基因编码并经翻译后修饰加工。研究发现OPN在多种疾病中直接参与免疫与炎症反应过程，在肾结石、子痫前期、心血管疾病、子宫内膜异位症及癌症等病理状态中发挥重要作用。作为连接炎症与癌变过程的关键细胞外基质分子，其在肿瘤学领域具有重要意义。方法：本系统评价基于PICO原则，探讨"骨桥蛋白是否与子宫内膜癌患者的病因及预后存在相关性？"通过检索PubMed、Scholar、Embase、Scopus等数据库，采用"骨桥蛋白"与"肿瘤"、"子宫内膜癌"等关键词组合进行文献筛选，依据科研相关性原则选取英文文献进行初步分析。结果：经引文检索共获得9篇相关文献。研究表明，在子宫内膜层面，OPN参与血管生成、转移、组织重塑异常、免疫应答、细胞粘附与迁移等多种生物学过程。结论：OPN通过明确的直接相关性及其在疾病诊断与预后评估中的潜在作用参与子宫内膜癌发生发展，正日益受到研究者的广泛关注。
Osteopontin Expression and Its Role in Endometrial Cancer: A Systematic Review
肿瘤(癌症)患者之家