Background/Objectives:Duodenum-preserving pancreatic head resection (DPPHR) preserves digestive and absorptive functions better than pancreaticoduodenectomy (PD). Zinc is primarily absorbed in the duodenum and proximal jejunum and plays a critical role in nutritional maintenance and pancreatic regeneration. However, no studies have compared the postoperative pancreatic volume and serum zinc levels between DPPHR and PD.Methods:We retrospectively analyzed 41 patients who underwent DPPHR (n= 23) or subtotal stomach-preserving PD (n= 18) for low-grade pancreatic malignancies at our institution. The remnant pancreatic volumes on postoperative day 7 and 1 year were measured via computed tomography. Nutritional parameters, including serum albumin, prognostic nutritional index (PNI), and serum zinc levels, were compared between the groups. Serum zinc levels were evaluated in patients with DPPHR (n= 11) or PD (n= 7).Results:The DPPHR group demonstrated significantly better preservation of remnant pancreatic volume on postoperative day 7 and 1 year compared to the PD group (p= 0.045 andp= 0.041, respectively). Volume maintenance ratios were also significantly higher in the DPPHR group. Serum albumin levels at 1 year postoperatively were significantly better in the DPPHR group, although no significant difference was found in the PNI. Among patients evaluated for serum zinc, the DPPHR group showed significantly higher zinc levels compared to the PD group (80.3 vs. 65.8 μg/dL,p= 0.017).Conclusions:DPPHR preserves remnant pancreatic volume and maintains serum zinc levels better than PD, potentially contributing to improved postoperative nutritional status and quality of life. Further prospective studies with larger cohorts are warranted to validate these findings.
**背景/目的：** 保留十二指肠的胰头切除术（DPPHR）在维持消化与吸收功能方面优于胰十二指肠切除术（PD）。锌主要在十二指肠和近端空肠吸收，对营养维持和胰腺再生具有关键作用。然而，目前尚无研究比较DPPHR与PD术后胰腺体积及血清锌水平的差异。 **方法：** 我们回顾性分析了本院41例因低度恶性胰腺肿瘤接受DPPHR（n=23）或保留胃次全切除术的PD（n=18）的患者。通过计算机断层扫描测量术后第7天及1年的残余胰腺体积。比较两组间的营养参数，包括血清白蛋白、预后营养指数（PNI）及血清锌水平。血清锌水平在DPPHR组（n=11）和PD组（n=7）中进行了评估。 **结果：** 与PD组相比，DPPHR组在术后第7天及1年的残余胰腺体积保留显著更优（分别为p=0.045和p=0.041）。DPPHR组的体积维持比率也显著更高。术后1年，DPPHR组的血清白蛋白水平显著优于PD组，但PNI未见显著差异。在评估血清锌的患者中，DPPHR组的锌水平显著高于PD组（80.3 vs. 65.8 μg/dL，p=0.017）。 **结论：** DPPHR较PD能更好地保留残余胰腺体积并维持血清锌水平，可能有助于改善术后营养状态及生活质量。未来需要更大样本的前瞻性研究进一步验证这些发现。
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