Background/Objectives:Over the past few decades, the incidence of melanoma has been steadily rising. In Hungary, the National Institute of Oncology serves as the national center for the diagnosis and treatment of malignancies, including melanoma. This study aims to analyze our patients’ data, providing a comprehensive characterization of melanoma across the country.Methods:We systematically analyzed the clinico-pathological data of melanoma patients treated in the Department of Oncodermatology between 2001 and 2018. Prognostic parameters were collected from the Hospital Information System of the Institute, including gender, age, tumor location, exulceration of primary lesion, Clark level, and Breslow thickness. In addition, survival analysis was also performed.Results:A total of 6267 melanoma patients were included in the study, with a slight predominance of female cases. The most common tumor location was the trunk. Female patients and younger age groups were more likely to present with lower Breslow thickness, while tumors in the head region were associated with increased thickness. Over the study period, the annual median Breslow thickness showed a significant decline. Female gender, younger age, and lower Breslow thickness was correlated with improved overall survival. Over time, the studied patient population exhibited better outcomes.Conclusions:Despite the rising incidence of melanoma in Hungary, the annual median Breslow thickness in our studied patient group showed a decreasing trend, accompanied by improved mortality outcomes. This highlights the critical role of secondary prevention measures and their effectiveness, as well as the impact of novel therapeutic advancements.
背景/目的：过去几十年间，黑色素瘤发病率持续上升。匈牙利国家肿瘤研究所作为全国恶性肿瘤（包括黑色素瘤）诊疗中心，本研究旨在通过分析患者数据，全面呈现该国黑色素瘤的流行病学特征。方法：我们系统分析了2001年至2018年间肿瘤皮肤病科收治的黑色素瘤患者临床病理资料。从研究所医院信息系统收集预后参数，包括性别、年龄、肿瘤部位、原发灶溃疡情况、Clark分级和Breslow厚度，并进行了生存分析。结果：研究共纳入6267例黑色素瘤患者，女性病例略占优势。最常见发病部位为躯干。女性患者和年轻人群组更易出现较低的Breslow厚度，而头部区域肿瘤则与厚度增加相关。研究期间，年度中位Breslow厚度呈现显著下降趋势。女性、年轻年龄及较低Breslow厚度与改善的总生存期相关。随时间推移，研究人群的临床结局持续改善。结论：尽管匈牙利黑色素瘤发病率不断攀升，但研究人群的年度中位Breslow厚度呈下降趋势，同时死亡率结局得到改善。这凸显了二级预防措施及其有效性的关键作用，以及新型治疗进展带来的积极影响。
肿瘤(癌症)患者之家