Organoids are three-dimensional (3D) structures that mimic the architecture and functionality of human organs, providing a novel approach to study diseases such as colorectal cancer (CRC). This review aims to explore the impact of organoids on understanding CRC and their potential use in exploring therapeutic outcomes. Colorectal cancer, characterized by the transformation of colonic epithelial cells into adenomas and carcinomas, remains one of the top causes of cancer-related morbidity and mortality worldwide. Traditional two-dimensional (2D) cell cultures fail to replicate the tumor microenvironment in an effective manner, which highlights the need for advanced 3D models. Organoids preserve the genetic and phenotypic properties of the original tumors, allowing for improved disease modeling, drug screening, and personalized medicine applications. When using patient-derived organoids (PDOs), researchers can gain insights into CRC initiation, progression, and treatment outcome. Ultimately, organoids represent an encouraging platform for improving therapeutic strategies for CRC, potentially leading to better patient outcomes through tailored treatment approaches.
类器官是一种三维（3D）结构，能够模拟人体器官的架构与功能，为研究结直肠癌等疾病提供了新途径。本综述旨在探讨类器官在理解结直肠癌方面的作用及其在探索治疗效果中的潜在应用价值。结直肠癌以结肠上皮细胞转化为腺瘤和癌变为特征，目前仍是全球癌症相关发病率和死亡率的主要原因之一。传统的二维（2D）细胞培养无法有效模拟肿瘤微环境，这凸显了对先进三维模型的需求。类器官保留了原始肿瘤的遗传和表型特性，有助于改进疾病建模、药物筛选及个体化医疗应用。通过使用患者来源的类器官，研究人员能够深入理解结直肠癌的发生、发展过程及治疗结果。最终，类器官为优化结直肠癌治疗策略提供了极具前景的平台，有望通过个体化治疗方案改善患者预后。
The Role of Organoids in Advancing Colorectal Cancer Research: Insights and Future Directions
肿瘤(癌症)患者之家