Background/Objectives: Gastric cancer (GC) is the fifth leading cause of cancer-related mortality. CLDN18.2 is a tight junction protein, expressed in gastric mucosa and is considered as a novel therapeutic target. Even though CLDN18.2 is associated with various components of the tumor microenvironment and the relation with clinical histopathological parameters has been widely studied, there is no sufficient data on the associations of CLDN18.2 expression and the components of the tumor microenvironment. This systematic review aims to gather and present all available data about the correlation of CLDN 18.2 expression and the tumor microenvironment.Methods: The research questions were systematically formulated using the PICO model to ensure clarity and precision, and the PRISMA flow diagram was constructed to detail the study selection process.Results: Sixteen original articles were retrieved. The major finding of this study was the positive correlation between CLDN18.2 expression and CD8+ T cells, neutrophils and cancer-associated fibroblasts. No correlation was found between CLDN18.2 expression and Tregs and B cells. For the remaining components of the microenvironment, there are contradictory data about their correlation with the expression of CLDN18.2.Conclusions: The tumor microenvironment plays a critical role in cancer progression and needs to be studied more thoroughly.
背景/目的：胃癌是全球癌症相关死亡的第五大主要原因。CLDN18.2是一种紧密连接蛋白，在胃黏膜中表达，被视为一种新型治疗靶点。尽管CLDN18.2与肿瘤微环境的多种成分相关，且其与临床病理参数的关系已得到广泛研究，但目前关于CLDN18.2表达与肿瘤微环境成分之间关联的数据尚不充分。本系统综述旨在汇总并呈现所有关于CLDN18.2表达与肿瘤微环境相关性的现有数据。 方法：采用PICO模型系统构建研究问题以确保清晰度和精确性，并构建PRISMA流程图详细说明研究筛选过程。 结果：共检索到16篇原始研究。本研究的主要发现是CLDN18.2表达与CD8+ T细胞、中性粒细胞及癌症相关成纤维细胞呈正相关。未发现CLDN18.2表达与调节性T细胞及B细胞存在相关性。对于微环境的其他成分，其与CLDN18.2表达的相关性存在矛盾数据。 结论：肿瘤微环境在癌症进展中起着关键作用，需要更深入的研究。
Correlation of CLDN18.2 and Tumor Microenvironment in Gastric Cancer: A Systematic Review
肿瘤(癌症)患者之家