Background/Objectives:Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide, posing a substantial health and economic burden. Despite advances in screening and treatment, significant socioeconomic and healthcare-related disparities persist across European Union (EU) member states. This study aims to identify trends and inequality in CRC burden over time and to explore the relationship between country-level socioeconomic and healthcare indicators and CRC burden across EU member states.Methods:Age-standardized mortality, years lived with disability (YLD), years of life lost (YLL), and disability-adjusted life years (DALY) rates were extracted from Global Burden of Diseases Study 2021 for 24 EU countries. Socioeconomic and healthcare indicators were extracted from Eurostat between 2005 and 2021. The Gini index was calculated to evaluate CRC-related health inequality, and generalized linear mixed models were used to assess the link between indicators and disease burden.Results:The Gini index for age-standardized YLDs declined from 0.19 to 0.12 between 1990 and 2021, while inequality in YLL (from 0.11 to 0.16), DALY (from 0.11 to 0.15), and mortality rates (from 0.12 to 0.14) increased. The number of practicing physicians (p< 0.05) and higher levels of education (p< 0.001) were related to lower death, DALY, YLD, and YLL rates. Conversely, greater income inequality was linked to higher mortality, DALY, and YLL rates (p< 0.05).Conclusions:Our findings underscore that, in addition to expanding organized screening programs, enhancing physician availability and addressing socioeconomic inequalities are essential for reducing the burden of CRC.
背景/目的：结直肠癌是全球癌症相关发病率和死亡率的主要原因，构成重大的健康与经济负担。尽管筛查与治疗手段不断进步，欧盟成员国之间仍存在显著的社会经济和医疗保健相关差异。本研究旨在分析欧盟成员国结直肠癌疾病负担随时间变化的趋势及不平等性，并探讨国家层面的社会经济与医疗保健指标与结直肠癌负担之间的关联。 方法：从《2021年全球疾病负担研究》中提取24个欧盟国家的年龄标准化死亡率、伤残生存年、生命损失年及伤残调整生命年数据。社会经济与医疗保健指标来源于2005年至2021年欧盟统计局数据。通过计算基尼系数评估结直肠癌相关健康不平等性，并采用广义线性混合模型分析各项指标与疾病负担的关联。 结果：1990年至2021年间，年龄标准化伤残生存年的基尼系数从0.19降至0.12，而生命损失年（0.11升至0.16）、伤残调整生命年（0.11升至0.15）及死亡率（0.12升至0.14）的不平等性均呈上升趋势。执业医师数量（p<0.05）与更高教育水平（p<0.001）与较低的死亡率、伤残调整生命年、伤残生存年及生命损失年相关。相反，收入不平等程度加剧与更高的死亡率、伤残调整生命年及生命损失年相关（p<0.05）。 结论：本研究结果强调，除扩大规范化筛查项目外，提高医师可及性并解决社会经济不平等问题，对减轻结直肠癌疾病负担至关重要。
肿瘤(癌症)患者之家