文章：

NOD2基因多态性与结直肠癌风险关联性的最新系统评价与荟萃分析

NOD2Polymorphisms and Their Association with Colorectal Cancer Risk: An Updated Systematic Review and Meta-Analysis

原文发布日期：15 June 2025

DOI: 10.3390/cancers17121999

类型: Article

开放获取: 是

英文摘要：

Background:Nucleotide-binding oligomerization domain-containing protein 2, encoded byNOD2, can trigger chronic gut inflammation that leads to colorectal cancer (CRC). However, studies that have investigated the association ofNOD2polymorphisms and CRC susceptibility have produced inconsistent findings. To clarify this relationship, a meta-analysis was conducted to integrate data from previous studies to achieve a more precise evaluation of the risk association.Methods:PubMed, Scopus, and Web of Science databases were systematically searched to identify relevant studies on the association ofNOD2polymorphisms with CRC risk. Genetic risk association was quantitatively assessed under five genetic models: homozygous, heterozygous, dominant, recessive, and allele. Thirteen studies, comprising 5,013 cases and 4,463 controls, were included in this study. FourNOD2polymorphisms were investigated in these studies, namely rs2066842, rs2066844, rs2066845, and rs2066847.Results:Of these, only rs2066845 and rs2066847 were found to be significantly associated with increased CRC risk (rs2066845, heterozygous OR = 1.544, 95% CI = 1.014–2.349, P = 0.043; dominant OR = 1.561, 95% CI = 1.035–2.354, P = 0.034; allele OR = 1.572, 95% CI = 1.040–2.375, P = 0.032; rs2066847, heterozygous OR = 1.321, 95% CI = 1.060–1.647, P = 0.013; dominant OR = 1.402, 95% CI = 1.147–1.713, P = 0.001; allele OR = 1.345, 95% CI = 1.088–1.663, P = 0.006).Conclusions:In conclusion, theNOD2rs2066845 and rs2066847 polymorphisms are associated with an increased risk of CRC and may potentially serve as predisposition biomarkers for the cancer.

摘要翻译： 

背景：由NOD2基因编码的核苷酸结合寡聚化结构域蛋白2可引发慢性肠道炎症，进而导致结直肠癌的发生。然而，关于NOD2基因多态性与结直肠癌易感性关联的研究结果存在不一致性。为明确该关联，本研究通过荟萃分析整合既往研究数据，以期获得更精确的风险评估。 方法：系统检索PubMed、Scopus和Web of Science数据库中关于NOD2基因多态性与结直肠癌风险关联的相关研究。在纯合子、杂合子、显性、隐性和等位基因五种遗传模型下进行遗传风险定量评估。本研究共纳入13项研究，包含5,013例病例和4,463例对照。这些研究共探讨了四种NOD2基因多态性位点：rs2066842、rs2066844、rs2066845和rs2066847。 结果：其中仅rs2066845和rs2066847位点多态性与结直肠癌风险增加显著相关（rs2066845：杂合模型OR=1.544，95% CI=1.014–2.349，P=0.043；显性模型OR=1.561，95% CI=1.035–2.354，P=0.034；等位基因模型OR=1.572，95% CI=1.040–2.375，P=0.032；rs2066847：杂合模型OR=1.321，95% CI=1.060–1.647，P=0.013；显性模型OR=1.402，95% CI=1.147–1.713，P=0.001；等位基因模型OR=1.345，95% CI=1.088–1.663，P=0.006）。 结论：NOD2基因rs2066845和rs2066847位点多态性与结直肠癌风险增加相关，可能作为该癌症的易感性生物标志物。

原文链接：

NOD2Polymorphisms and Their Association with Colorectal Cancer Risk: An Updated Systematic Review and Meta-Analysis