Malignancies of the female upper reproductive tract, especially endometrial and ovarian cancers, generate a significant burden for women worldwide. The possible etiopathogenetic role of chronic human papillomavirus (HPV) infection in the carcinogenesis of the female upper genital tract is neither clearly established not completely understood. Therefore, we performed a literature review, using the PubMed and SCOPUS electronic databases, of the prevalence of HPV DNA in endometrial, primary fallopian tube, ovarian, and primary peritoneal cancers, as well as uterine sarcomas. The present investigation covered 35 studies from different countries on various continents. Overall, the prevalence of HPV was approximately 15% in all the above cancers. HPV DNA was isolated from 11%, 0%, 0%, and 14% of endometrial carcinomas, uterine sarcomas, primary fallopian tube cancers, and ovarian malignant neoplasms, respectively. No relevant studies on primary peritoneal cancers were retrieved. The predominant HPV strain from tumors of the upper female reproductive tract, regardless of the tumor site, was HPV-16, followed by HPV-18. The HPV DNA identified was exclusively from subtypes HPV-6, HPV-11, HPV-16, HPV-18, and HPV-33, which are responsible for the development of not only cervical cancer, but also condylomata acuminata. The findings of the present review indicate that HPV vaccination might prove to be a useful strategy in the prevention of HPV-related carcinomas of the upper genital tract in women.
女性上生殖道恶性肿瘤，尤其是子宫内膜癌和卵巢癌，给全球女性带来了沉重的疾病负担。慢性人乳头瘤病毒（HPV）感染在女性上生殖道癌变过程中的潜在病因学作用尚未明确确立，也未完全阐明。因此，我们利用PubMed和SCOPUS电子数据库，对子宫内膜癌、原发性输卵管癌、卵巢癌、原发性腹膜癌以及子宫肉瘤中HPV DNA的检出率进行了文献综述。本次研究涵盖了来自各大洲不同国家的35项研究。总体而言，在上述所有癌症中，HPV的检出率约为15%。具体而言，子宫内膜癌、子宫肉瘤、原发性输卵管癌和卵巢恶性肿瘤中HPV DNA的检出率分别为11%、0%、0%和14%。未检索到关于原发性腹膜癌的相关研究。无论肿瘤部位如何，女性上生殖道肿瘤中主要的HPV毒株均为HPV-16，其次是HPV-18。检出的HPV DNA仅限于HPV-6、HPV-11、HPV-16、HPV-18和HPV-33亚型，这些亚型不仅与宫颈癌的发生有关，也与尖锐湿疣的发病相关。本综述的研究结果表明，HPV疫苗接种可能被证明是预防女性上生殖道HPV相关癌症的有效策略。
肿瘤(癌症)患者之家