文章：

伽马刀治疗后前庭神经鞘瘤生长预测因素：一项系统性综述

Predictors of Growth of Vestibular Schwannoma After Gamma Knife Treatment: A Systematic Review

原文发布日期：14 June 2025

DOI: 10.3390/cancers17121993

类型: Article

开放获取: 是

英文摘要：

Background: GKRS shows a high success rate in controlling growth of vestibular schwannoma, but a small number of tumors still grow after treatment. However, only a few studies have investigated the predictive factors of this growth.Objective: Here, we aim to explore the growth determinants of vestibular schwannoma after GKRS.Methods: This paper has analyzed literature published between 2000 and 2024 from PubMed, EMBASE, and Cochrane databases. Potential determinants, including age, gender, tumor volume, radiation dose, tumor location, and imaging characteristics, have been reviewed.Conclusions: We have found that initial tumor volume, pretreatment growth rate, and imaging ADC value potentially predict growth after GKRS. These findings provide a reference for further optimizing personalized treatment in vestibular schwannoma care.

摘要翻译： 

背景：伽玛刀放射外科（GKRS）在控制前庭神经鞘瘤生长方面显示出较高的成功率，但仍有少数肿瘤在治疗后继续生长。然而，目前仅有少数研究探讨了这种生长的预测因素。 目的：本研究旨在探索前庭神经鞘瘤在GKRS治疗后生长的决定因素。 方法：本文分析了2000年至2024年间PubMed、EMBASE和Cochrane数据库中发表的文献，对年龄、性别、肿瘤体积、放射剂量、肿瘤位置及影像学特征等潜在决定因素进行了综述。 结论：研究发现，初始肿瘤体积、治疗前生长速率及影像学ADC值可能预测GKRS后的肿瘤生长。这些发现为进一步优化前庭神经鞘瘤的个体化治疗提供了参考依据。

原文链接：

Predictors of Growth of Vestibular Schwannoma After Gamma Knife Treatment: A Systematic Review