The WHO estimates that nearly 10–15% of cancers have a known viral etiology, although this number is likely an underestimate. In glioblastoma (GBM), the most common primary brain malignancy, viral associations have been proposed and investigated without a definitive etiology. Viral–host interactions are known to alter cellular growth and stem cell programming, as well as modulate innate immune signaling. However, in GBM, the multifaceted role of endogenous or exogenous viral expression remains unclear. Here, we provide a review of common viral associations in GBM and discuss how these viruses modulate intrinsic cellular processes to enhance anti-viral immune response or suppress anti-tumor immunity.
世界卫生组织估计，近10-15%的癌症具有已知的病毒病因，尽管这一数字很可能被低估。在胶质母细胞瘤（GBM）——最常见的原发性脑恶性肿瘤中，病毒关联已被提出并研究，但尚未确定明确的病因。已知病毒-宿主相互作用会改变细胞生长和干细胞编程，并调节先天免疫信号。然而，在GBM中，内源性或外源性病毒表达的多方面作用仍不清楚。本文综述了GBM中常见的病毒关联，并讨论了这些病毒如何调节内在细胞过程以增强抗病毒免疫反应或抑制抗肿瘤免疫。
肿瘤(癌症)患者之家